Abstract：
:Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely committed to centromere formation), are unusual in that they can apparently occur in a DNA-sequence-independent manner. Current evidence indicates the involvement of epigenetic influences in these early steps. A number of epigenetic mechanisms that can affect centromere chromatin organization have been proposed. Here, the characteristics of these mechanisms and their relative roles as possible primary triggers for centromerization are discussed in the light of recent data.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Choo KHdoi
10.1016/s0962-8924(00)01739-6subject
Has Abstractpub_date
2000-05-01 00:00:00pages
182-8issue
5eissn
0962-8924issn
1879-3088pii
S0962-8924(00)01739-6journal_volume
10pub_type
杂志文章,评审abstract：:Stem cell niches are specialized microenvironments where pluripotent cells are maintained to provide undifferentiated cells for the formation of new tissues and organs. The balance between stem cell maintenance within the niche and differentiation of cells that exit it is regulated by local cell-cell communication, to...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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abstract：:Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2). This has major implications for s...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/0962-8924(92)90125-7
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2017.05.002
更新日期：2017-08-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2006.03.006
更新日期：2006-05-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2007-02-01 00:00:00
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journal_title：Trends in cell biology
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pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 评论,杂志文章
doi：10.1016/s0962-8924(03)00148-x
更新日期：2003-08-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2002-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.08.004
更新日期：2020-10-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2015.01.002
更新日期：2015-06-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2018.06.008
更新日期：2018-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(98)01360-9
更新日期：1998-10-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2005-12-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2007.10.004
更新日期：2008-01-01 00:00:00
abstract：:The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(03)00101-6
更新日期：2003-06-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/s0962-8924(01)02083-9
更新日期：2001-09-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2002-07-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.05.002
更新日期：2020-08-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2009-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.08.007
更新日期：2008-11-01 00:00:00
abstract：:Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in th...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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更新日期：2012-11-01 00:00:00
abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/s0962-8924(01)02182-1
更新日期：2001-11-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2004.01.003
更新日期：2004-03-01 00:00:00
abstract：:Owing to the sessile nature of their lifestyle, plants have to respond to a wide range of signals, such as the force of the wind or the impedance of the soil, to entrain their development to prevailing environmental conditions. Indeed, mechanically responsive growth has been documented in plants for many years but new...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.02.005
更新日期：2009-05-01 00:00:00
