Abstract:
:At least three genes that play crucial roles in dorsal-ventral patterning of the Drosophila embryo appear to encode extracellular proteases. These proteases are involved in the generation of localized extracellular ligands for membrane receptors. Because the sequences of these gene products closely resemble those of mammalian enzymes that have been studied in detail biochemically, it is possible to draw on the wealth of information on the biochemical mechanisms that regulate protease activity to make inferences about how proteases can be used to generate spatial asymmetries within fields of cells.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Hecht PM,Anderson KVdoi
10.1016/0962-8924(92)90246-jsubject
Has Abstractpub_date
1992-07-01 00:00:00pages
197-202issue
7eissn
0962-8924issn
1879-3088pii
096289249290246Jjournal_volume
2pub_type
杂志文章abstract::Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in m...
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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abstract::Gene editing in zebrafish has begun to reveal discordance between mutant phenotypes and those associated with knockdown via morpholino oligonucleotides (MOs). These studies suggest that MOs should not be used as a standalone tool and underscore the need for guidelines that require defined mutants to assess gene functi...
journal_title:Trends in cell biology
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更新日期:2016-02-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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abstract::DNA double-strand breaks (DSBs) are the most toxic DNA lesions given their oncogenic potential. Nevertheless, programmed DSBs (prDSBs) contribute to several biological processes. Formation of prDSBs is the 'price to pay' to achieve these essential biological functions. Generated by domesticated PiggyBac transposases, ...
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更新日期:2020-02-01 00:00:00
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journal_title:Trends in cell biology
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更新日期:2006-05-01 00:00:00
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journal_title:Trends in cell biology
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pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2018.02.006
更新日期:2018-06-01 00:00:00
abstract::A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is ...
journal_title:Trends in cell biology
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更新日期:1998-07-01 00:00:00
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
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更新日期:2011-09-01 00:00:00
abstract::The morphological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently. A prerequisite for each origin of multicellularity was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in comp...
journal_title:Trends in cell biology
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更新日期:2010-12-01 00:00:00
abstract::Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to ...
journal_title:Trends in cell biology
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doi:10.1016/j.tcb.2008.11.001
更新日期:2009-01-01 00:00:00
abstract::Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now well established that signaling by integrins mediates many of these effects. Ten years of research has seen integrin signaling advance on many fronts towards a molecular understanding of the control mechanisms. Most strik...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(01)02152-3
更新日期:2001-12-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2003.12.003
更新日期:2004-02-01 00:00:00
abstract::Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can le...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01658-x
更新日期:1999-11-01 00:00:00