Abstract:
:The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counterparts. A wide variety of pathogenic bacteria have been investigated using zebrafish models, providing unprecedented resolution of the cellular response to infection in vivo. In this review, we illustrate how zebrafish models have contributed to our understanding of cellular microbiology by providing an in vivo platform to study host-pathogen interactions from the single cell to whole animal level. We also highlight discoveries made from zebrafish infection that hold great promise for translation into novel therapies for humans.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Torraca V,Mostowy Sdoi
10.1016/j.tcb.2017.10.002subject
Has Abstractpub_date
2018-02-01 00:00:00pages
143-156issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(17)30181-2journal_volume
28pub_type
杂志文章,评审abstract::The number of invited women speakers at scientific meetings is much less than their proportion in a field. This means that women have fewer venues to present their research, less opportunity to increase their professional network, and smaller chances of promotion and financial support. The paucity of women speakers al...
journal_title:Trends in cell biology
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abstract::The power of fluorescence microscopy to study cellular structures and macromolecular complexes spans a wide range of size scales, from studies of cell behavior and function in physiological 3D environments to understanding the molecular architecture of organelles. At each length scale, the challenge in 3D imaging is t...
journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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