Mitotic disassembly of the mammalian Golgi apparatus.

abstract：:Chloroplasts depend on the nucleus for much of their proteome. Consequently, strong transcriptional coordination exists between the genomes, which is attuned to the developmental and physiological needs of the organelle. Recent studies highlight that the post-translational modifier ubiquitin adds another layer to plas...

journal_title：Trends in cell biology

authors： Hua Z,Vierstra RD

更新日期：2016-01-01 00:00:00

abstract：:The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole mediators of exchange between the nucleus and the cytoplasm. Small molecules pass through the NPCs unchallenged; however, large macromolecules a...

journal_title：Trends in cell biology

authors： Rout MP,Aitchison JD,Magnasco MO,Chait BT

更新日期：2003-12-01 00:00:00

abstract：:Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...

journal_title：Trends in cell biology

authors： Dalal K,Duong F

更新日期：2011-09-01 00:00:00

abstract：:The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genomic instability, whi...

journal_title：Trends in cell biology

authors： Byrum AK,Vindigni A,Mosammaparast N

更新日期：2019-09-01 00:00:00

abstract：:A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated prote...

journal_title：Trends in cell biology

authors： Tsegaye MA,Schafer ZT

更新日期：2017-11-01 00:00:00

abstract：:An important aspect of cell behaviour is that DNA replication happens only once per cell cycle. Replicated DNA is unable to re-replicate until cell division has occurred. Unreplicated DNA is in a replication-competent or 'licensed' state. The ability to replicate is lost in S phase and regained following passage throu...

journal_title：Trends in cell biology

authors： Romanowski P,Madine MA

更新日期：1996-05-01 00:00:00

abstract：:Endosomal protein sorting governs the fate of many physiologically important proteins involved in a panoply of cellular functions. Recent discoveries have revealed a vital role for endosomally localised branched actin patches in facilitating protein sorting. The formation of the actin patches has been shown to require...

journal_title：Trends in cell biology

authors： Seaman MN,Gautreau A,Billadeau DD

更新日期：2013-11-01 00:00:00

abstract：:Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context...

journal_title：Trends in cell biology

authors： Fafián-Labora JA,O'Loghlen A

更新日期：2020-08-01 00:00:00

abstract：:The proliferation of eukaryotic cells is a highly regulated process that depends on the precise duplication of chromosomal DNA in each cell cycle. Regulation of the replication licensing system, which promotes the assembly of complexes of proteins termed Mcm2-7 onto replication origins, is responsible for preventing r...

journal_title：Trends in cell biology

authors： Blow JJ,Hodgson B

更新日期：2002-02-01 00:00:00

abstract：:Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensel...

journal_title：Trends in cell biology

authors： Saffi GT,Botelho RJ

更新日期：2019-08-01 00:00:00

abstract：:The ability of cells to utilize cholesterol derived from lipoprotein is important in plasma membrane biosynthesis, steroidogenesis and the regulation of sterol synthesis. While the endocytosis of lipoprotein-derived cholesterol has been well characterized, the subsequent events that mediate its post-lysosomal intracel...

journal_title：Trends in cell biology

authors： Evans RM

更新日期：1994-05-01 00:00:00

abstract：:Asymmetric cell divisions are central to the generation of cell-fate diversity because factors that are present in a mother cell and distributed unequally at cell division can generate distinct daughters. The process o f asymmetric cell division can be described as consisting of three steps: setting up an asymmetric c...

journal_title：Trends in cell biology

authors： Gönczy P,Hyman AA

更新日期：1996-10-01 00:00:00

abstract：:The synthesis, assembly and organisation of structural and motor proteins during muscle formation requires temporal and spatial control directed by specialized chaperones. For example, alphaB-crystallin, GimC and TRiC facilitate the assembly of sarcomeric proteins such as desmin and actin. Recent studies have demonstr...

journal_title：Trends in cell biology

authors： Kim J,Löwe T,Hoppe T

更新日期：2008-06-01 00:00:00

abstract：:Research performed over the past decade has transformed apoptosis from a distinctive form of cell death known only by its characteristic morphology and genomic destruction to an increasingly well understood cellular disassembly pathway remarkable for its complex and multifaceted regulation. Here, we summarize current ...

journal_title：Trends in cell biology

authors： Kaufmann SH,Hengartner MO

更新日期：2001-12-01 00:00:00

abstract：:The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicat...

journal_title：Trends in cell biology

authors： Guo W,Novick P

更新日期：2004-02-01 00:00:00

abstract：:Cellular organization of the cytoskeleton, assembly of intracellular signaling complexes and movement of membrane receptors into supramolecular activation complexes (SMACs) are crucial prerequisites for lymphocyte activation and function. Full T-cell activation requires costimulatory signals in addition to antigen-med...

journal_title：Trends in cell biology

authors： Krawczyk C,Penninger JM

更新日期：2001-05-01 00:00:00

abstract：:In vitro cell biology has become an effective way to identify molecules responsible for membrane traffic. We have used this approach to study the assembly and budding of coated pits. So far our system has allowed us to identify a high-affinity binding site for the AP2 subunit on the inside surface of plasma membranes,...

journal_title：Trends in cell biology

authors： Anderson RG

更新日期：1993-06-01 00:00:00

abstract：:Research on fibroblast biology in three-dimensional collagen matrices offers new opportunities to understand the reciprocal and adaptive interactions that occur between cells and surrounding matrix in a tissue-like environment. Such interactions are integral to the regulation of connective tissue morphogenesis and dyn...

journal_title：Trends in cell biology

authors： Grinnell F

更新日期：2003-05-01 00:00:00

abstract：:Owing to the sessile nature of their lifestyle, plants have to respond to a wide range of signals, such as the force of the wind or the impedance of the soil, to entrain their development to prevailing environmental conditions. Indeed, mechanically responsive growth has been documented in plants for many years but new...

journal_title：Trends in cell biology

authors： Monshausen GB,Gilroy S

更新日期：2009-05-01 00:00:00

abstract：:Our present understanding of intracellular protein degradation developed from an attempt to understand the metabolic stability of proteins in cells. With the unravelling of its complex biochemical machinery has come a realization that protein degradation plays an important role in the most crucial events in the cell c...

journal_title：Trends in cell biology

authors： Kirschner M

更新日期：1999-12-01 00:00:00

abstract：:Genetic instability contributes to the origin of cancer as well as to the ability of cancer cells to become resistant to various therapies. Because of this, cytotoxic rather than cytostatic therapies might be most effective against this disease. Many oncogenes and tumor suppressors mediate their effects by interfering...

journal_title：Trends in cell biology

authors： Huang P,Oliff A

更新日期：2001-08-01 00:00:00

abstract：:When starved, the fission yeast Schizosaccharomyces pombe responds by producing mating factors or pheromones that signal to cells of the opposite sex to initiate mating. Like its distant relative Saccharomyces cerevisiae, cells of the two mating types of S. pombe each produce a distinct pheromone that binds to recepto...

journal_title：Trends in cell biology

authors： Nielsen O

更新日期：1993-02-01 00:00:00

abstract：:If eukaryotes arose through a merger between archaea and bacteria, what did the first true eukaryotic cell look like? A major step toward an answer came with the discovery of Lokiarchaeum, an archaeon whose genome encodes small GTPases related to those used by eukaryotes to regulate membrane traffic. Although 'Loki' c...

journal_title：Trends in cell biology

authors： Dey G,Thattai M,Baum B

更新日期：2016-07-01 00:00:00

abstract：:Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now well established that signaling by integrins mediates many of these effects. Ten years of research has seen integrin signaling advance on many fronts towards a molecular understanding of the control mechanisms. Most strik...

journal_title：Trends in cell biology

authors： Schwartz MA

更新日期：2001-12-01 00:00:00

abstract：:Nuclear receptors comprise a large family of proteins that shares a common structure and mechanism of action. Members of this family, first cloned 20 years ago, are regulated by small lipophilic signaling molecules such as steroid hormones, retinoids and thyroid hormone. More recently, the characterization of proteins...

journal_title：Trends in cell biology

authors： Benoit G,Malewicz M,Perlmann T

更新日期：2004-07-01 00:00:00

abstract：:The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...

journal_title：Trends in cell biology

authors： Storz P

更新日期：2007-01-01 00:00:00

abstract：:Lymphocyte migration from high endothelial venules into lymphoid organs is mediated by a sequence of interactions between cell adhesion molecules on lymphocytes and those on the vascular endothelial cells that line the vessels. recent studies suggest that the so-called lymphocyte homing receptors and vascular addressi...

journal_title：Trends in cell biology

authors： Ager A

更新日期：1994-09-01 00:00:00

abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...

journal_title：Trends in cell biology

authors： Goldstein B,King N

更新日期：2016-11-01 00:00:00

abstract：:Damage to any tissue triggers a cascade of events that leads to rapid repair of the wound - if the tissue is skin, then repair involves re-epithelialization, formation of granulation tissue and contraction of underlying wound connective tissues. This concerted effort by the wounded cell layers is accompanied by, and m...

journal_title：Trends in cell biology

authors： Martin P,Leibovich SJ

更新日期：2005-11-01 00:00:00

abstract：:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization o...

journal_title：Trends in cell biology

authors： Baas PW,Ahmad FJ

更新日期：2001-06-01 00:00:00