Abstract：
:Nuclear receptors comprise a large family of proteins that shares a common structure and mechanism of action. Members of this family, first cloned 20 years ago, are regulated by small lipophilic signaling molecules such as steroid hormones, retinoids and thyroid hormone. More recently, the characterization of proteins that resemble nuclear receptors (referred to as orphan receptors) has resulted in the determination of novel signaling pathways. However, many orphan-receptor ligands remain unidentified, and recent structural studies of the binding domains for orphan-receptor ligands suggest that not all of these receptors use ligand binding in a classical way. Notably, it is now evident that some orphan receptors lack the capacity for ligand binding, which suggests that they are regulated by alternative, ligand-independent mechanisms.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Benoit G,Malewicz M,Perlmann Tdoi
10.1016/j.tcb.2004.05.007subject
Has Abstractpub_date
2004-07-01 00:00:00pages
369-76issue
7eissn
0962-8924issn
1879-3088pii
S0962892404001394journal_volume
14pub_type
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