Collective cell migration: guidance principles and hierarchies.

abstract：:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

journal_title：Trends in cell biology

authors： Nicholson AL,Pasquinelli AE

更新日期：2019-03-01 00:00:00

abstract：:Substantial progress has been made in recent years toward understanding the molecular mechanisms by which tumor cells, and the supporting stroma, degrade confining matrix during migration. Significant attention has been focused on understanding the biology of several dynamic and distinct, but remarkably related, cell ...

journal_title：Trends in cell biology

authors： McNiven MA

更新日期：2013-01-01 00:00:00

abstract：:It was once believed that common mechanisms underpin the transfer of proteins across the membrane systems of organelles such as mitochondria, chloroplasts and peroxisomes. Now that many of the core components of the translocases have been indentified, results discussed at a recent conference [Max-Delbrück-Centrum Symp...

journal_title：Trends in cell biology

authors： Kunau WH,Agne B,Girzalsky W

更新日期：2001-09-01 00:00:00

abstract：:Natural killer (NK) cells employ an unconventional mode of recognition: they kill target cells that lack ligands for inhibitory NK cell receptors. Activation of NK cytotoxicity is tightly controlled by inhibitory receptors that recruit and activate the tyrosine phosphatase SHP-1 through the tyrosine-phosphorylated [I/...

journal_title：Trends in cell biology

authors： Burshtyn DN,Long EO

更新日期：1997-12-01 00:00:00

abstract：:The availability of green fluorescent protein (GFP) as a tracer for observing proteins in living cells has revolutionized cell biology and spurred an intensive search for GFP variants with novel characteristics, additional autofluorescent proteins and alternative techniques of protein labelling. Two recent studies - o...

journal_title：Trends in cell biology

authors： Falk M

更新日期：2002-09-01 00:00:00

abstract：:Germ cells in many vertebrate and invertebrate species initiate gametogenesis by forming groups of interconnected cells known as germline cysts. Recent studies using Xenopus, mouse and Drosophila are beginning to uncover the cellular and molecular mechanisms that control germline cyst formation and, in conjunction wit...

journal_title：Trends in cell biology

authors： Pepling ME,de Cuevas M,Spradling AC

更新日期：1999-07-01 00:00:00

abstract：:Autophagy is a highly conserved process that allows cells, tissues and organs to survive onslaughts such as nutrient deprivation, inflammation, hypoxia and other stresses. The core component proteins that regulate autophagy are well known, and the formation of a double-membrane structure that encompasses cytosolic car...

journal_title：Trends in cell biology

authors： McEwan DG,Dikic I

更新日期：2011-04-01 00:00:00

abstract：:Research performed over the past decade has transformed apoptosis from a distinctive form of cell death known only by its characteristic morphology and genomic destruction to an increasingly well understood cellular disassembly pathway remarkable for its complex and multifaceted regulation. Here, we summarize current ...

journal_title：Trends in cell biology

authors： Kaufmann SH,Hengartner MO

更新日期：2001-12-01 00:00:00

abstract：:Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...

journal_title：Trends in cell biology

authors： Joshi U,Houwman JA,van der Sluijs P

更新日期：2018-10-01 00:00:00

abstract：:Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al., Cell, 2019) used the discovery of an inhibitor of xenophagy, SopF,...

journal_title：Trends in cell biology

authors： Pao KC,Rape M

更新日期：2019-10-01 00:00:00

abstract：:Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is widely used during development and by many types of adult stem cells during tissue homeostasis and regeneration. ACD can be regulated by extrinsic cues, such as signaling molecules, as well as by intrinsic factors, such as orga...

journal_title：Trends in cell biology

authors： Xie J,Wooten M,Tran V,Chen X

更新日期：2017-07-01 00:00:00

abstract：:Cellular organization of the cytoskeleton, assembly of intracellular signaling complexes and movement of membrane receptors into supramolecular activation complexes (SMACs) are crucial prerequisites for lymphocyte activation and function. Full T-cell activation requires costimulatory signals in addition to antigen-med...

journal_title：Trends in cell biology

authors： Krawczyk C,Penninger JM

更新日期：2001-05-01 00:00:00

abstract：:Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There ar...

journal_title：Trends in cell biology

authors： Carragher NO,Frame MC

更新日期：2004-05-01 00:00:00

abstract：:Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensel...

journal_title：Trends in cell biology

authors： Saffi GT,Botelho RJ

更新日期：2019-08-01 00:00:00

abstract：:An important aspect of cell behaviour is that DNA replication happens only once per cell cycle. Replicated DNA is unable to re-replicate until cell division has occurred. Unreplicated DNA is in a replication-competent or 'licensed' state. The ability to replicate is lost in S phase and regained following passage throu...

journal_title：Trends in cell biology

authors： Romanowski P,Madine MA

更新日期：1996-05-01 00:00:00

abstract：:Recent characterization of the major protein-targeting systems in both yeast and mammalian cells has provided detailed descriptions of how cellular transport processes operate. Increasingly, however, novel protein-sorting mechanisms are being uncovered. These newly discovered 'alternative' mechanisms of protein sortin...

journal_title：Trends in cell biology

authors： Klionsky DJ

更新日期：1997-06-01 00:00:00

abstract：:Ras proteins regulate cell growth and differentiation, and their mutation plays a major, direct role in causing human cancer. For years, their precise function has been a mystery. One of the pathways Ras controls has recently been identified. It consists of a cascade of kinases (Raf, MEK and MAP kinases) that transmit...

journal_title：Trends in cell biology

authors： McCormick F

更新日期：1994-10-01 00:00:00

abstract：:At least three genes that play crucial roles in dorsal-ventral patterning of the Drosophila embryo appear to encode extracellular proteases. These proteases are involved in the generation of localized extracellular ligands for membrane receptors. Because the sequences of these gene products closely resemble those of m...

journal_title：Trends in cell biology

authors： Hecht PM,Anderson KV

更新日期：1992-07-01 00:00:00

abstract：:There is a pronounced tendency among cell biologists to focus on qualitative aspects of cell physiology. The remarkable accomplishments of evolution in creating cells can only be fully appreciated, however, by combining this qualitative analysis with a quantitative assessment of cellular constituents and processes. He...

journal_title：Trends in cell biology

authors： Yewdell JW

更新日期：2001-07-01 00:00:00

abstract：:Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

journal_title：Trends in cell biology

authors： Cassereau J,Courdavault V,Nägerl UV

更新日期：2020-12-29 00:00:00

abstract：:Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the cross...

journal_title：Trends in cell biology

authors： Thelen AM,Zoncu R

更新日期：2017-11-01 00:00:00

abstract：:Cells possess an extensive network of components to safeguard proteome integrity and maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines in performance, as may be the case during aging, newly synthesized proteins are no longer able to fold efficiently and metastable proteins lose ...

journal_title：Trends in cell biology

authors： Hipp MS,Park SH,Hartl FU

更新日期：2014-09-01 00:00:00

abstract：:The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. PIs are among the most versatile signaling molecules known, with key roles in receptor-mediated signal transduction, actin remodeling and membrane trafficking. Recent s...

journal_title：Trends in cell biology

authors： Downes CP,Gray A,Lucocq JM

更新日期：2005-05-01 00:00:00

abstract：:Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals...

journal_title：Trends in cell biology

authors： Driskell RR,Watt FM

更新日期：2015-02-01 00:00:00

abstract：:The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...

journal_title：Trends in cell biology

authors： Needleman D

更新日期：2015-12-01 00:00:00

abstract：:Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discu...

journal_title：Trends in cell biology

authors： Wasserman S

更新日期：1998-03-01 00:00:00

abstract：:The power of fluorescence microscopy to study cellular structures and macromolecular complexes spans a wide range of size scales, from studies of cell behavior and function in physiological 3D environments to understanding the molecular architecture of organelles. At each length scale, the challenge in 3D imaging is t...

journal_title：Trends in cell biology

authors： Fischer RS,Wu Y,Kanchanawong P,Shroff H,Waterman CM

更新日期：2011-12-01 00:00:00

abstract：:In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these ...

journal_title：Trends in cell biology

authors： Andersen DS,Colombani J,Léopold P

更新日期：2013-07-01 00:00:00

abstract：:Cyclin-dependent kinase 2 (CDK2) regulates diverse aspects of the mammalian cell cycle. Most cancer cells contain mutations in the pathways that control CDK2, and CDK2 activity has received much attention as a target for cancer therapy. However, a recent report demonstrating that some cancer cells can proliferate with...

journal_title：Trends in cell biology

authors： Grim JE,Clurman BE

更新日期：2003-08-01 00:00:00

abstract：:A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is ...

journal_title：Trends in cell biology

authors： Odorizzi G,Cowles CR,Emr SD

更新日期：1998-07-01 00:00:00