Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.


:Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There are important roles for tyrosine kinases, extracellular signal-regulated protein kinase/mitogen-activated protein kinase signalling, and intracellular and extracellular proteases during actin and adhesion modulation. Dysregulation of these is associated with tumour cell invasion. In this article, we discuss established roles for these signalling pathways, as well as the functional interplay between them in controlling the migratory phenotype.


Trends Cell Biol


Trends in cell biology


Carragher NO,Frame MC




Has Abstract


2004-05-01 00:00:00














  • Turning up the Green Light.

    abstract::Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Cassereau J,Courdavault V,Nägerl UV

    更新日期:2020-12-29 00:00:00

  • Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?

    abstract::A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminatin...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Sesti F,Liu S,Cai SQ

    更新日期:2010-01-01 00:00:00

  • Joining the cell survival squad: an emerging role for protein kinase CK2.

    abstract::Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ahmed K,Gerber DA,Cochet C

    更新日期:2002-05-01 00:00:00

  • The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

    abstract::Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can le...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Bischoff JR,Plowman GD

    更新日期:1999-11-01 00:00:00

  • Polarizing without a c(l)ue.

    abstract::Most cells polarize in response to an asymmetric signal but some can spontaneously establish a discrete axis of polarity in the absence of a directional cue. Many mathematical models predict that locally acting positive feedback loops and globally acting negative regulators are required for pattern formation. Here, we...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Sohrmann M,Peter M

    更新日期:2003-10-01 00:00:00

  • Epithelial organization, cell polarity and tumorigenesis.

    abstract::Epithelial cells comprise the foundation for the majority of organs in the mammalian body, and are the source of approximately 90% of all human cancers. Characteristically, epithelial cells form intercellular adhesions, exhibit apical/basal polarity, and orient their mitotic spindles in the plane of the epithelial she...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: McCaffrey LM,Macara IG

    更新日期:2011-12-01 00:00:00

  • Diverse evolutionary paths to cell adhesion.

    abstract::The morphological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently. A prerequisite for each origin of multicellularity was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in comp...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Abedin M,King N

    更新日期:2010-12-01 00:00:00

  • Molecular mechanisms of DNA double strand break repair.

    abstract::DNA double-strand breaks (DSBs) are major threats to the genomic integrity of cells. If not taken care of properly, they can cause chromosome fragmentation, loss and translocation, possibly resulting in carcinogenesis. Upon DSB formation, cell-cycle checkpoints are triggered and multiple DSB repair pathways can be act...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Kanaar R,Hoeijmakers JH,van Gent DC

    更新日期:1998-12-01 00:00:00

  • Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation.

    abstract::During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is invol...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Nankoe SR,Sever S

    更新日期:2006-12-01 00:00:00

  • Orchestration of cell surface proteins by Rab11.

    abstract::The organization of cells into interconnected structures such as animal tissues requires a sophisticated system directing receptors and adhesion proteins to the cell surface. The Rab11 small G proteins (Rab11a, b, and Rab25) of the Ras superfamily are master regulators of the surface expression of receptors and adhesi...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Welz T,Wellbourne-Wood J,Kerkhoff E

    更新日期:2014-07-01 00:00:00

  • Endogenous Fluorescence Tagging by CRISPR.

    abstract::Fluorescent proteins have revolutionized biomedical research as they are easy to use for protein tagging, cope without fixation or permeabilization, and thus, enable live cell imaging in various models. Current methods allow easy and quick integration of fluorescent markers to endogenous genes of interest. In this rev...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Bukhari H,Müller T

    更新日期:2019-11-01 00:00:00

  • ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum.

    abstract::The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and ion storage. To maintain its function, it is turned over constitutively, and even more actively under certain stress conditions. Quality con...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Chino H,Mizushima N

    更新日期:2020-05-01 00:00:00

  • MHC class II molecules: transport pathways for antigen presentation.

    abstract::During biosynthesis, MHC class II molecules travel through the endocytic pathway and interact with antigenic peptides before their stable insertion in the plasma membrane. The process of class II association with these peptides and their final deposition at the cell surface are essential steps in boosting specific ant...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Wubbolts R,Fernandez-Bona M,Neefjes J

    更新日期:1997-03-01 00:00:00

  • Role of MINOS in mitochondrial membrane architecture and biogenesis.

    abstract::Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: van der Laan M,Bohnert M,Wiedemann N,Pfanner N

    更新日期:2012-04-01 00:00:00

  • PDZ domains in synapse assembly and signalling.

    abstract::Synaptic junctions are highly specialized structures designed to promote the rapid and efficient transmission of signals from the presynaptic terminal to the postsynaptic membrane within the central nervous system. Proteins containing PDZ domains play a fundamental organizational role at both the pre- and postsynaptic...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Garner CC,Nash J,Huganir RL

    更新日期:2000-07-01 00:00:00

  • p130Cas: a versatile scaffold in signaling networks.

    abstract::The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular signaling events. Although these proteins do not have enzymatic or transcriptional activity, they spatially and temporally control signaling events through their ability to undergo changes in phosphorylation and to associate w...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Defilippi P,Di Stefano P,Cabodi S

    更新日期:2006-05-01 00:00:00

  • Lipid Metabolism in Regulation of Macrophage Functions.

    abstract::Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue repair in response to tissue injury. Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we re...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Yan J,Horng T

    更新日期:2020-12-01 00:00:00

  • Cell Biology and Microbiology: A Continuous Cross-Feeding.

    abstract::Microbiology and cell biology both involve the study of cells, albeit at different levels of complexity and scale. Interactions between both fields during the past 25 years have led to major conceptual and technological advances that have reshaped the whole biology landscape and its biomedical applications. ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Pizarro-Cerdá J,Cossart P

    更新日期:2016-07-01 00:00:00

  • Coordinating the events of the meiotic prophase.

    abstract::Meiosis is a specialized type of cell division leading to the production of gametes. During meiotic prophase I, homologous chromosomes interact with each other and form bivalents (pairs of homologous chromosomes). Three major meiotic processes--chromosome pairing, synapsis and recombination--are involved in the format...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Pawlowski WP,Cande WZ

    更新日期:2005-12-01 00:00:00

  • Tales of Detailed Poly(A) Tails.

    abstract::Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Nicholson AL,Pasquinelli AE

    更新日期:2019-03-01 00:00:00

  • Lysosome Fission: Planning for an Exit.

    abstract::Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensel...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Saffi GT,Botelho RJ

    更新日期:2019-08-01 00:00:00

  • Interface between Physics and Biology: Training a New Generation of Creative Bilingual Scientists.

    abstract::Whereas physics seeks for universal laws underlying natural phenomena, biology accounts for complexity and specificity of molecular details. Contemporary biological physics requires people capable of working at this interface. New programs prepare scientists who transform respective disciplinary views into innovative ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Riveline D,Kruse K

    更新日期:2017-08-01 00:00:00

  • Hematopoietic Reprogramming Entangles with Hematopoiesis.

    abstract::Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Wei C,Yu P,Cheng L

    更新日期:2020-10-01 00:00:00

  • Flagellar regeneration in Chlamydomonas: a model system for studying organelle assembly.

    abstract::How do the many different components of an organelle assemble into a functional structure at an appropriate place and time? Flagellar regeneration by the biflagellate green alga Chlamydomonas is one experimental system in which genetics, biochemistry and ultrastructural analysis are being combined to investigate the a...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Johnson KA,Rosenbaum JL

    更新日期:1993-05-01 00:00:00

  • Centrosome duplication: of rules and licenses.

    abstract::Most microtubule arrays in animal cells, including the bipolar spindle required for cell division, are organized by centrosomes. Thus, strict control of centrosome numbers is crucial for accurate chromosome segregation. Each centrosome comprises two centrioles, which need to be duplicated exactly once in every cell cy...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Nigg EA

    更新日期:2007-05-01 00:00:00

  • Photoreceptor Discs: Built Like Ectosomes.

    abstract::The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Spencer WJ,Lewis TR,Pearring JN,Arshavsky VY

    更新日期:2020-11-01 00:00:00

  • From Planar Cell Polarity to Ciliogenesis and Back: The Curious Tale of the PPE and CPLANE proteins.

    abstract::Why some genes are more popular than others remains an open question, but one example of this phenomenon involves the genes controlling planar cell polarity (PCP), the polarization of cells within a plane of a tissue. Indeed, the so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been extensive...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Adler PN,Wallingford JB

    更新日期:2017-05-01 00:00:00

  • Nuclear Architecture: Past and Future Tense.

    abstract::The architecture of the interphase nucleus remains a treasure trove for explorers of the 3D folding of macromolecules, like DNA, and of their related functions. Only recently has there been insight into how transient interactions of the genome and its associated proteins, in space and time, facilitate transcription, r...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Gasser SM

    更新日期:2016-07-01 00:00:00

  • Centromerization.

    abstract::Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely com...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Choo KH

    更新日期:2000-05-01 00:00:00

  • The SecY complex: conducting the orchestra of protein translocation.

    abstract::Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Dalal K,Duong F

    更新日期:2011-09-01 00:00:00