Abstract:
:Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There are important roles for tyrosine kinases, extracellular signal-regulated protein kinase/mitogen-activated protein kinase signalling, and intracellular and extracellular proteases during actin and adhesion modulation. Dysregulation of these is associated with tumour cell invasion. In this article, we discuss established roles for these signalling pathways, as well as the functional interplay between them in controlling the migratory phenotype.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Carragher NO,Frame MCdoi
10.1016/j.tcb.2004.03.011subject
Has Abstractpub_date
2004-05-01 00:00:00pages
241-9issue
5eissn
0962-8924issn
1879-3088pii
S0962892404000856journal_volume
14pub_type
杂志文章,评审abstract::Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O2) and nutrient supply. Whereas normal cells modulate anabolic and catabolic pathways in response to changes in nutrient availability, cancer cells exhibit unregulated growth even under nutrient scarci...
journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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更新日期:2021-02-01 00:00:00
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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