Abstract:
:Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There are important roles for tyrosine kinases, extracellular signal-regulated protein kinase/mitogen-activated protein kinase signalling, and intracellular and extracellular proteases during actin and adhesion modulation. Dysregulation of these is associated with tumour cell invasion. In this article, we discuss established roles for these signalling pathways, as well as the functional interplay between them in controlling the migratory phenotype.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Carragher NO,Frame MCdoi
10.1016/j.tcb.2004.03.011subject
Has Abstractpub_date
2004-05-01 00:00:00pages
241-9issue
5eissn
0962-8924issn
1879-3088pii
S0962892404000856journal_volume
14pub_type
杂志文章,评审abstract::Every heart beat is not equal. As physiological demands of the cardiovascular system change, cardiac myocytes modulate contractile parameters including the rate and force of contraction. Adaptive responses require the sensing of biomechanical signals involving the interface between the contractile cytoskeleton (myofib...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2004.01.003
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abstract::There is a pronounced tendency among cell biologists to focus on qualitative aspects of cell physiology. The remarkable accomplishments of evolution in creating cells can only be fully appreciated, however, by combining this qualitative analysis with a quantitative assessment of cellular constituents and processes. He...
journal_title:Trends in cell biology
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doi:10.1016/s0962-8924(01)02030-x
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abstract::Plant seeds store nitrogen by accumulating storage proteins in protein bodies within various compartments of the endomembrane system. The prolamin storage proteins of some cereal species are normally retained and assembled into protein bodies within the ER. Yet, these proteins lack a C-terminal KDEL/HDEL signal, sugge...
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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abstract::Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1alpha (HIF-1alp...
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journal_title:Trends in cell biology
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abstract::The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors...
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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