Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

Abstract:

:Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There are important roles for tyrosine kinases, extracellular signal-regulated protein kinase/mitogen-activated protein kinase signalling, and intracellular and extracellular proteases during actin and adhesion modulation. Dysregulation of these is associated with tumour cell invasion. In this article, we discuss established roles for these signalling pathways, as well as the functional interplay between them in controlling the migratory phenotype.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Carragher NO,Frame MC

doi

10.1016/j.tcb.2004.03.011

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

241-9

issue

5

eissn

0962-8924

issn

1879-3088

pii

S0962892404000856

journal_volume

14

pub_type

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