Abstract：
:The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential for photoreceptor viability. In this review, we describe recent breakthroughs in the understanding of disc morphogenesis, with a focus on the molecular mechanisms responsible for initiating disc formation from the ciliary membrane. We highlight the discoveries that this mechanism evolved from an innate ciliary process of releasing small extracellular vesicles, or ectosomes, and that both disc formation and ectosome release rely on the actin cytoskeleton.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Spencer WJ,Lewis TR,Pearring JN,Arshavsky VYdoi
10.1016/j.tcb.2020.08.005subject
Has Abstractpub_date
2020-11-01 00:00:00pages
904-915issue
11eissn
0962-8924issn
1879-3088pii
S0962-8924(20)30165-3journal_volume
30pub_type
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