Abstract:
:Meiosis is a specialized type of cell division leading to the production of gametes. During meiotic prophase I, homologous chromosomes interact with each other and form bivalents (pairs of homologous chromosomes). Three major meiotic processes--chromosome pairing, synapsis and recombination--are involved in the formation of bivalents. Many recent reports have uncovered complex networks of interactions between these processes. Chromosome pairing is largely dependent on the initiation and progression of recombination in fungi, mammals and plants, but not in Caenorhabditis elegans or Drosophila. Synapsis and recombination are also tightly linked. Understanding the coordination between chromosome pairing, synapsis and recombination lends insight into many poorly explained aspects of meiosis, such as the nature of chromosome homology recognition.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Pawlowski WP,Cande WZdoi
10.1016/j.tcb.2005.10.005subject
Has Abstractpub_date
2005-12-01 00:00:00pages
674-81issue
12eissn
0962-8924issn
1879-3088pii
S0962-8924(05)00249-7journal_volume
15pub_type
杂志文章,评审abstract::During the past 15 years mass spectrometry (MS)-based analyses have become established as the method of choice for direct protein identification and measurement. Owing to the remarkable improvements in the sensitivity and resolution of MS instruments, this technology has revolutionised the opportunities available for ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2013.10.010
更新日期:2014-04-01 00:00:00
abstract::Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling. ...
journal_title:Trends in cell biology
pub_type: 评论,杂志文章
doi:10.1016/j.tcb.2018.04.005
更新日期:2018-07-01 00:00:00
abstract::Germ cells in many vertebrate and invertebrate species initiate gametogenesis by forming groups of interconnected cells known as germline cysts. Recent studies using Xenopus, mouse and Drosophila are beginning to uncover the cellular and molecular mechanisms that control germline cyst formation and, in conjunction wit...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01594-9
更新日期:1999-07-01 00:00:00
abstract::Members of the transforming growth factor-beta (TGF-beta) family play pivotal roles in development and disease. These cytokines elicit their pleiotropic effects on cells, including endothelial and mural cells, through specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription fa...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2010.06.006
更新日期:2010-09-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) regulates cell proliferation, differentiation and apoptosis, and TGF-beta-related proteins have key roles in development, tissue homeostasis and disease. Upon binding to their cell surface receptors, TGF-beta family proteins signal through Smads to induce changes in gene expr...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2009.05.008
更新日期:2009-08-01 00:00:00
abstract::Mucins are heavily glycosylated high molecular weight glycoproteins, which are involved in the protection and lubrication of luminal epithelial surfaces. Transmembrane mucins also engage in signal transduction, through extracellular domain-mediated ligand binding or by interacting with receptors for growth and differe...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2006.07.006
更新日期:2006-09-01 00:00:00
abstract::The power of fluorescence microscopy to study cellular structures and macromolecular complexes spans a wide range of size scales, from studies of cell behavior and function in physiological 3D environments to understanding the molecular architecture of organelles. At each length scale, the challenge in 3D imaging is t...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.09.008
更新日期:2011-12-01 00:00:00
abstract::DNA double-strand breaks (DSBs) are major threats to the genomic integrity of cells. If not taken care of properly, they can cause chromosome fragmentation, loss and translocation, possibly resulting in carcinogenesis. Upon DSB formation, cell-cycle checkpoints are triggered and multiple DSB repair pathways can be act...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(98)01383-x
更新日期:1998-12-01 00:00:00
abstract::Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Galpha subunits of heterotrimeric G proteins. Their ability to dampen signalling via Galphai-, Galphaq- and Galpha12/13-coupled pathways makes them crucial players in mediating the multitude...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01515-9
更新日期:1999-04-01 00:00:00
abstract::Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:
更新日期:1998-02-01 00:00:00
abstract::Epithelial cells comprise the foundation for the majority of organs in the mammalian body, and are the source of approximately 90% of all human cancers. Characteristically, epithelial cells form intercellular adhesions, exhibit apical/basal polarity, and orient their mitotic spindles in the plane of the epithelial she...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.06.005
更新日期:2011-12-01 00:00:00
abstract::Lymphocyte migration from high endothelial venules into lymphoid organs is mediated by a sequence of interactions between cell adhesion molecules on lymphocytes and those on the vascular endothelial cells that line the vessels. recent studies suggest that the so-called lymphocyte homing receptors and vascular addressi...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(94)90234-8
更新日期:1994-09-01 00:00:00
abstract::Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue repair in response to tissue injury. Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we re...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2020.09.006
更新日期:2020-12-01 00:00:00
abstract::Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely com...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(00)01739-6
更新日期:2000-05-01 00:00:00
abstract::Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There ar...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2004.03.011
更新日期:2004-05-01 00:00:00
abstract::Microbiology has a long way to go. Microbes are ubiquitous, and all other life forms in the biosphere exist solely because of them, but, as less than 1% of microorganisms can be grown in the laboratory, more than a century of research has revealed only the tip of the iceberg concerning this most crucial of life scienc...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Recent findings provide evidence for dynamic and highly regulated dual subcellular localization of catalase, a hydrogen peroxide (H2O2)-metabolizing enzyme, in peroxisomes and the cytosol. These data suggest a number of important implications for the field of oxidative stress biology. ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2020.12.006
更新日期:2021-01-06 00:00:00
abstract::The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genomic instability, whi...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2019.06.005
更新日期:2019-09-01 00:00:00
abstract::Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can le...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(99)01658-x
更新日期:1999-11-01 00:00:00
abstract::The acid-secreting gastric parietal cell has a unique secretory membrane system. This membrane system exists in an inactive (non-secreting) and an active (secreting) form. The current accepted model to explain the transformation events associated with the conversion of the non-secreting membrane to the secreting membr...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(96)81010-5
更新日期:1996-02-01 00:00:00
abstract::Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2020.12.007
更新日期:2020-12-29 00:00:00
abstract::Proteins of the cyclophilin family display two intriguing properties. On the one hand, they are the intracellular receptors for the immunosuppressive drug cyclosporin A (CsA); on the other hand, they function in vitro as enzymes that catalyse slow steps in protein folding. A dissection of the role of CsA in mediating ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(92)90200-7
更新日期:1992-09-01 00:00:00
abstract::Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O2) and nutrient supply. Whereas normal cells modulate anabolic and catabolic pathways in response to changes in nutrient availability, cancer cells exhibit unregulated growth even under nutrient scarci...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2014.06.001
更新日期:2014-08-01 00:00:00
abstract::Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2020.08.004
更新日期:2020-10-01 00:00:00
abstract::Plant seeds store nitrogen by accumulating storage proteins in protein bodies within various compartments of the endomembrane system. The prolamin storage proteins of some cereal species are normally retained and assembled into protein bodies within the ER. Yet, these proteins lack a C-terminal KDEL/HDEL signal, sugge...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(93)90033-w
更新日期:1993-12-01 00:00:00
abstract::Understanding the basic mechanisms underlying chromatin dynamics during DNA replication in eukaryotic cells is of fundamental importance. Beyond DNA compaction, chromatin organization represents a means to regulate genome function. Thus, the inheritance and maintenance of the DNA sequence, along with its organization ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2008.10.002
更新日期:2009-01-01 00:00:00
abstract::Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(02)02279-1
更新日期:2002-05-01 00:00:00
abstract::The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines po...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(92)90057-t
更新日期:1992-03-01 00:00:00
abstract::DNA double-strand breaks (DSBs) are the most toxic DNA lesions given their oncogenic potential. Nevertheless, programmed DSBs (prDSBs) contribute to several biological processes. Formation of prDSBs is the 'price to pay' to achieve these essential biological functions. Generated by domesticated PiggyBac transposases, ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2019.11.005
更新日期:2020-02-01 00:00:00
abstract::Every heart beat is not equal. As physiological demands of the cardiovascular system change, cardiac myocytes modulate contractile parameters including the rate and force of contraction. Adaptive responses require the sensing of biomechanical signals involving the interface between the contractile cytoskeleton (myofib...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2004.01.003
更新日期:2004-03-01 00:00:00