Abstract:
:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of higher eukaryotes. In addition, the functions of Id proteins are integrated with cell-cycle-regulatory pathways orchestrated by cyclin-dependent kinases and the retinoblastoma protein. Here, some of the recent advances that highlight the importance of Id proteins as regulatory intermediates for coordinating differentiation-linked gene expression with cell-cycle control in response to extracellular signalling are reviewed.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Norton JD,Deed RW,Craggs G,Sablitzky Fsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
58-65issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(98)80013-5journal_volume
8pub_type
杂志文章,评审abstract::An important aspect of cell behaviour is that DNA replication happens only once per cell cycle. Replicated DNA is unable to re-replicate until cell division has occurred. Unreplicated DNA is in a replication-competent or 'licensed' state. The ability to replicate is lost in S phase and regained following passage throu...
journal_title:Trends in cell biology
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