Abstract:
:Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conservation in the motor and light chain-binding domains (LCBDs) of these myosins, recent studies have revealed surprising diversity of function and regulation arising from isoform-specific differences in these domains. Here we review the regulation of myosin-I function and localization by the motor and LCBDs.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Greenberg MJ,Ostap EMdoi
10.1016/j.tcb.2012.10.008subject
Has Abstractpub_date
2013-02-01 00:00:00pages
81-9issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(12)00200-0journal_volume
23pub_type
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