Caveolae: anchored, multifunctional platforms in the lipid ocean.

Abstract:

:The function of caveolae is hotly debated. It now seems clear that caveolae are stable membrane domains that are kept in place by the actin cytoskeleton. However, this stability can be perturbed, leading to caveolar internalization. Caveolae are important in the regulation of various signaling processes, such as nitric oxide activity, and in cholesterol efflux and cholesterol-ester uptake. Caveolin deficiency particularly affects the cardiovascular system and the lungs but, because the knockout mice are viable, none of the proposed functions appears to be essential. Rather than having a specific function, caveolae might be considered to be multifunctional organelles with a physiological role that varies depending on cell type and cellular needs.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

van Deurs B,Roepstorff K,Hommelgaard AM,Sandvig K

doi

10.1016/s0962-8924(02)00039-9

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

92-100

issue

2

eissn

0962-8924

issn

1879-3088

pii

S0962892402000399

journal_volume

13

pub_type

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