Abstract:
:The function of caveolae is hotly debated. It now seems clear that caveolae are stable membrane domains that are kept in place by the actin cytoskeleton. However, this stability can be perturbed, leading to caveolar internalization. Caveolae are important in the regulation of various signaling processes, such as nitric oxide activity, and in cholesterol efflux and cholesterol-ester uptake. Caveolin deficiency particularly affects the cardiovascular system and the lungs but, because the knockout mice are viable, none of the proposed functions appears to be essential. Rather than having a specific function, caveolae might be considered to be multifunctional organelles with a physiological role that varies depending on cell type and cellular needs.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
van Deurs B,Roepstorff K,Hommelgaard AM,Sandvig Kdoi
10.1016/s0962-8924(02)00039-9subject
Has Abstractpub_date
2003-02-01 00:00:00pages
92-100issue
2eissn
0962-8924issn
1879-3088pii
S0962892402000399journal_volume
13pub_type
杂志文章,评审abstract::Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant ...
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