Abstract:
:The acid-secreting gastric parietal cell has a unique secretory membrane system. This membrane system exists in an inactive (non-secreting) and an active (secreting) form. The current accepted model to explain the transformation events associated with the conversion of the non-secreting membrane to the secreting membrane, and vice versa, invokes membrane recycling of elongated vesicle structures. However, recent studies employing cryopreparation have shown that the non-secreting membrane in these cells is actually a complex network of helically coiled tubules. Here, we present an alternative model to explain how the membrane in parietal cells is activated to secrete HCl.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Pettitt JM,van Driel IR,Toh BH,Gleeson PAdoi
10.1016/0962-8924(96)81010-5subject
Has Abstractpub_date
1996-02-01 00:00:00pages
49-53issue
2eissn
0962-8924issn
1879-3088pii
0962-8924(96)81010-5journal_volume
6pub_type
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