Abstract：
:Nuclear proteins are transported from the cytoplasm into the nucleus via nuclear envelope pore complexes (NPCs). At the molecular level, the mechanisms responsible for this transport remain obscure. However, it is known that, for many proteins, the process requires ATP and proceeds against formidable nucleocytoplasmic concentration gradients. Therefore, the NPC is often thought of as an active transport site. In this article, Philip Paine presents the alternative hypothesis that, on current evidence, protein translocation across the nuclear envelope and accumulation in the nucleus can equally well be explained by facilitated transport through the NPC and subsequent intranuclear binding.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Paine PLdoi
10.1016/0962-8924(93)90096-jsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
325-9issue
10eissn
0962-8924issn
1879-3088pii
096289249390096Jjournal_volume
3pub_type
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