Abstract：
:Signaling through the highly conserved Wingless/Wnt pathway plays a crucial role in a diverse array of developmental processes, many of which depend upon the precise regulation of Wingless/Wnt signaling levels. Recent evidence has indicated that the intracellular trafficking of Wingless/Wnt signaling components can result in significant changes in the level of signaling. Here, we examine three mechanisms through which intracellular trafficking might regulate Wingless signaling--the degradation of Wingless, its transport and the transduction of its signal. The intracellular trafficking of several Wingless/Wnt signaling components, including LRP5, LRP6, Dishevelled and Axin, as well as the functional implications of protein localization on Wingless/Wnt signaling, will be discussed.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Seto ES,Bellen HJdoi
10.1016/j.tcb.2003.11.004subject
Has Abstractpub_date
2004-01-01 00:00:00pages
45-53issue
1eissn
0962-8924issn
1879-3088pii
S0962892403002812journal_volume
14pub_type
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