Abstract：
:The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and ion storage. To maintain its function, it is turned over constitutively, and even more actively under certain stress conditions. Quality control of the ER is mediated primarily by two pathways: the ubiquitin-proteasome system and autophagy (termed 'ER-phagy'). The identification of ER-phagy adaptor molecules has shed light on the mechanisms and physiological significance of ER-phagy. Here, we describe recent findings on various types of ER-phagy and present unanswered questions related to their mechanism and regulation.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Chino H,Mizushima Ndoi
10.1016/j.tcb.2020.02.001subject
Has Abstractpub_date
2020-05-01 00:00:00pages
384-398issue
5eissn
0962-8924issn
1879-3088pii
S0962-8924(20)30033-7journal_volume
30pub_type
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