Abstract:
:Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals, fibroblasts are highly responsive to Wnt-regulated signals from the overlying epidermis, which can act both locally, via extracellular matrix (ECM) deposition, and via secreted factors that impact the behaviour of fibroblasts in different dermal locations. These findings may explain some of the changes that occur in connective tissue during wound healing and cancer progression.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Driskell RR,Watt FMdoi
10.1016/j.tcb.2014.10.001subject
Has Abstractpub_date
2015-02-01 00:00:00pages
92-9issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(14)00177-9journal_volume
25pub_type
杂志文章,评审abstract::Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcripti...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2019.02.001
更新日期:2019-04-01 00:00:00
abstract::The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2006.11.003
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abstract::Microtubules have been regarded as essential structures for stable neuronal morphology but new studies are highlighting their role in dynamic neuronal processes. Recent work demonstrates that the microtubule cytoskeleton has an active role during different phases of neuronal polarization - microtubules and their stabi...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2009.08.006
更新日期:2009-12-01 00:00:00
abstract::Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo y...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2008.05.003
更新日期:2008-07-01 00:00:00
abstract::Mucins are heavily glycosylated high molecular weight glycoproteins, which are involved in the protection and lubrication of luminal epithelial surfaces. Transmembrane mucins also engage in signal transduction, through extracellular domain-mediated ligand binding or by interacting with receptors for growth and differe...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2006.07.006
更新日期:2006-09-01 00:00:00
abstract::Lymphocyte migration from high endothelial venules into lymphoid organs is mediated by a sequence of interactions between cell adhesion molecules on lymphocytes and those on the vascular endothelial cells that line the vessels. recent studies suggest that the so-called lymphocyte homing receptors and vascular addressi...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(94)90234-8
更新日期:1994-09-01 00:00:00
abstract::Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute to cellular transforma...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:1999-02-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
abstract::Despite their small size and lack of obvious intracellular structures, bacteria have a complex and dynamic intracellular organization. Recent work has shown that many proteins, and even regions of the chromosome, are localized to specific subcellular regions that can change over time, sometimes extraordinarily fast. P...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2000-11-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2020.12.006
更新日期:2021-01-06 00:00:00
abstract::Transfer of proteins and lipids between the various membrane-bound subcellular compartments of the eukaryotic cell is mediated by transport vesicles. The development of cell-free assays has allowed rapid progress towards a molecular description of the formation, or budding, of these vesicles. This article reviews and ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(91)90018-5
更新日期:1991-12-01 00:00:00
abstract::Meiosis is a specialized type of cell division leading to the production of gametes. During meiotic prophase I, homologous chromosomes interact with each other and form bivalents (pairs of homologous chromosomes). Three major meiotic processes--chromosome pairing, synapsis and recombination--are involved in the format...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2005.10.005
更新日期:2005-12-01 00:00:00
abstract::Substantial progress has been made in recent years toward understanding the molecular mechanisms by which tumor cells, and the supporting stroma, degrade confining matrix during migration. Significant attention has been focused on understanding the biology of several dynamic and distinct, but remarkably related, cell ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2012.08.009
更新日期:2013-01-01 00:00:00
abstract::A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule requir...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2010.12.005
更新日期:2011-04-01 00:00:00
abstract::The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(00)01727-x
更新日期:2000-04-01 00:00:00
abstract::Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conser...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2012.10.008
更新日期:2013-02-01 00:00:00
abstract::Chloroplasts depend on the nucleus for much of their proteome. Consequently, strong transcriptional coordination exists between the genomes, which is attuned to the developmental and physiological needs of the organelle. Recent studies highlight that the post-translational modifier ubiquitin adds another layer to plas...
journal_title:Trends in cell biology
pub_type: 评论,杂志文章
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abstract::The JAK-STAT signal-transduction pathway is utilized by a wide range of cytokines to regulate gene expression. Cytokines activate members of the JAK family o f protein tyrosine kinases, which in turn activate, by tyrosine phosphorylation, one or more STAT transcription factor family members. Activated STATs form dimer...
journal_title:Trends in cell biology
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abstract::Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocyto...
journal_title:Trends in cell biology
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更新日期:2002-12-01 00:00:00
abstract::Export signal sequences target newly synthesized proteins to the endoplasmic reticulum of eukaryotic cells and the plasma membrane of bacteria. All signal sequences contain a hydrophobic core region, but, despite this, they show great variation in both overall length and amino acid sequence. Recently, it has become cl...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(98)01360-9
更新日期:1998-10-01 00:00:00
abstract::Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:
更新日期:1998-02-01 00:00:00
abstract::In vitro cell biology has become an effective way to identify molecules responsible for membrane traffic. We have used this approach to study the assembly and budding of coated pits. So far our system has allowed us to identify a high-affinity binding site for the AP2 subunit on the inside surface of plasma membranes,...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(93)90205-f
更新日期:1993-06-01 00:00:00
abstract::Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2008.05.005
更新日期:2008-08-01 00:00:00
abstract::Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2016.08.005
更新日期:2016-11-01 00:00:00
abstract::Lysophosphatidic acid (LPA), the smallest and structurally simplest phospholipid, is a platelet-derived serum factor that evokes a wide range of biological effects, including stimulation of fibroblast proliferation, platelet aggregation, cellular motility, tumour cell invasiveness and neurite retraction. This review s...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(94)90144-9
更新日期:1994-06-01 00:00:00
abstract::The role o f iron in cell division, cell death and human disease has recently gained increased attention. The best studied process for iron uptake into mammalian cells involves traps ferrin and its receptor. This review discusses evidence supporting the existence of other routes by which iron can enter mammalian cells...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(96)10019-2
更新日期:1996-06-01 00:00:00
abstract::Actin is an ancient and abundant protein with well-established roles in fundamental processes ranging from cell migration to membrane transport. Most eukaryotic cells also contain at least eight actin-related proteins (ARPs) that are, themselves, conserved between organisms as divergent as yeast and mammals. Although ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2004.07.009
更新日期:2004-08-01 00:00:00