Abstract:
:The JAK-STAT signal-transduction pathway is utilized by a wide range of cytokines to regulate gene expression. Cytokines activate members of the JAK family o f protein tyrosine kinases, which in turn activate, by tyrosine phosphorylation, one or more STAT transcription factor family members. Activated STATs form dimers, translocate to the nucleus and bind to response elements to induce transcription. Recent findings are beginning to connect JAKs and STATs with other signalling pathways: JAKs may phosphorylate and activate signalling proteins other than STATs, and STATs can be phosphorylated by non-]AK tyrosine kinases. STAT activity can also be modulated by serine phosphorylation.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Briscoe J,Kohlhuber F,Müller Mdoi
10.1016/0962-8924(96)10028-3subject
Has Abstractpub_date
1996-09-01 00:00:00pages
336-40issue
9eissn
0962-8924issn
1879-3088pii
0962892496100283journal_volume
6pub_type
杂志文章abstract::Ciliary movement is powered by axonemal dynein. This article considers how a signal transduction cascade initiated at the cell membrane may activate outer dynein arms to change the velocity of microtubule sliding and the swimming speed of ciliated cells. For Paramecium, a critical event in the cascade is the cAMP-depe...
journal_title:Trends in cell biology
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doi:10.1016/0962-8924(93)90092-f
更新日期:1993-11-01 00:00:00
abstract::Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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abstract::The transport of protein through the secretory pathway of eukaryotic cells relies on small vesicular carriers, which mediate the movement of cargo between different compartments. Here, Meir Aridor and Bill Balch summarize what is currently known about the role of the cytosolic coat complexes in directing the formation...
journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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journal_title:Trends in cell biology
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更新日期:1993-05-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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journal_title:Trends in cell biology
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更新日期:2009-01-01 00:00:00
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journal_title:Trends in cell biology
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更新日期:2007-08-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章,评审
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更新日期:2006-11-01 00:00:00
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journal_title:Trends in cell biology
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更新日期:1998-11-01 00:00:00
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journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2009.10.003
更新日期:2010-01-01 00:00:00
abstract::In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these ...
journal_title:Trends in cell biology
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更新日期:2013-07-01 00:00:00
abstract::Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There ar...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2004.03.011
更新日期:2004-05-01 00:00:00
abstract::A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminatin...
journal_title:Trends in cell biology
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更新日期:2010-01-01 00:00:00
abstract::Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...
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doi:10.1016/j.tcb.2020.12.007
更新日期:2020-12-29 00:00:00
abstract::To battle adverse internal and external conditions and maintain homeostasis, diploid organisms employ various cellular processes, such as proliferation and apoptosis. In some tissues, an alternative mechanism, endoreplication, is employed toward similar goals. Endoreplication is an evolutionarily conserved cell cycle ...
journal_title:Trends in cell biology
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doi:10.1016/j.tcb.2018.02.006
更新日期:2018-06-01 00:00:00
abstract::Vesicular transport of proteins and lipids between distinct subcellular compartments is directly responsible for generating and maintaining the structure of the organelles of the secretory and endocytic pathways in eukaryotic cells. Rapid advances in a variety of experimental systems have resulted in the identificatio...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(92)90051-n
更新日期:1992-12-01 00:00:00
abstract::Understanding the basic mechanisms underlying chromatin dynamics during DNA replication in eukaryotic cells is of fundamental importance. Beyond DNA compaction, chromatin organization represents a means to regulate genome function. Thus, the inheritance and maintenance of the DNA sequence, along with its organization ...
journal_title:Trends in cell biology
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doi:10.1016/j.tcb.2008.10.002
更新日期:2009-01-01 00:00:00
abstract::The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors...
journal_title:Trends in cell biology
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更新日期:2006-12-01 00:00:00
abstract::Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome mis-segregation into a micronucleus or chromatin br...
journal_title:Trends in cell biology
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更新日期:2017-12-01 00:00:00
abstract::Natural killer (NK) cells employ an unconventional mode of recognition: they kill target cells that lack ligands for inhibitory NK cell receptors. Activation of NK cytotoxicity is tightly controlled by inhibitory receptors that recruit and activate the tyrosine phosphatase SHP-1 through the tyrosine-phosphorylated [I/...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/S0962-8924(97)01167-7
更新日期:1997-12-01 00:00:00
abstract::Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunct...
journal_title:Trends in cell biology
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更新日期:2015-06-01 00:00:00
abstract::Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway a...
journal_title:Trends in cell biology
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更新日期:1998-04-01 00:00:00
abstract::Endocytosis is essential for the entry of many viruses into cells. The primate lentiviruses [human immunodeficiency virus (HIV) 1 and 2, and the simian immunodeficiency viruses (SIVs)], however, use endocytosis in other aspects of their life cycles. Here, the authors describe the ways in which the endocytic pathway is...
journal_title:Trends in cell biology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
abstract::Polarised vesicle trafficking has been suggested to regulate cell migration. Understanding how this takes place has been complicated by the use of disparate assays and cellular models. Although polarised trafficking does occur in cell motility it is not clear which pathways are involved. We propose a model for migrati...
journal_title:Trends in cell biology
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更新日期:2010-02-01 00:00:00
abstract::The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...
journal_title:Trends in cell biology
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更新日期:2000-04-01 00:00:00
abstract::Ubiquinone (UQ; also known as coenzyme Q; CoQ) is a mobile component of the mitochondrial electron transport chain, where it acts as a pro-oxidant in its ubisemiquinone state. Despite this, UQ is also believed to be a membrane antioxidant. These properties place UQ at the center of hotly debated questions about how mi...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2015.12.007
更新日期:2016-05-01 00:00:00