Abstract：
:Vesicular transport of proteins and lipids between distinct subcellular compartments is directly responsible for generating and maintaining the structure of the organelles of the secretory and endocytic pathways in eukaryotic cells. Rapid advances in a variety of experimental systems have resulted in the identification of molecules involved in late steps of the transport process. This article presents a general paradigm for vesicular fusion and reviews the available experimental evidence.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Sztul ES,Melançon P,Howell KEdoi
10.1016/0962-8924(92)90051-nsubject
Has Abstractpub_date
1992-12-01 00:00:00pages
381-6issue
12eissn
0962-8924issn
1879-3088pii
096289249290051Njournal_volume
2pub_type
杂志文章abstract：:Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conser...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.10.008
更新日期：2013-02-01 00:00:00
abstract：:The nucleus is a spatially organized compartment. The most obvious way in which this is achieved is at the level of chromosomes. The positioning of chromosomes with respect to nuclear landmarks and with respect to each other is both non-random and cell-type specific. This suggests that cells possess molecular mechanis...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2011.08.001
更新日期：2011-12-01 00:00:00
abstract：:The number of invited women speakers at scientific meetings is much less than their proportion in a field. This means that women have fewer venues to present their research, less opportunity to increase their professional network, and smaller chances of promotion and financial support. The paucity of women speakers al...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2015.06.001
更新日期：2015-08-01 00:00:00
abstract：:The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole mediators of exchange between the nucleus and the cytoplasm. Small molecules pass through the NPCs unchallenged; however, large macromolecules a...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2003.10.007
更新日期：2003-12-01 00:00:00
abstract：:The power of fluorescence microscopy to study cellular structures and macromolecular complexes spans a wide range of size scales, from studies of cell behavior and function in physiological 3D environments to understanding the molecular architecture of organelles. At each length scale, the challenge in 3D imaging is t...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2011.09.008
更新日期：2011-12-01 00:00:00
abstract：:It is widely believed that calorie restriction (CR) can extend the lifespan of model organisms and protect against aging-related diseases. A potential CR mimetic is resveratrol, which may have beneficial effects against numerous diseases such as type 2 diabetes, cardiovascular diseases, and cancer in tissue culture an...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.07.004
更新日期：2012-10-01 00:00:00
abstract：:In higher eukaryotes, the vast majority of protein-coding genes contain introns that must be removed from precursor mRNA (pre-mRNA) with great precision by the spliceosome. Spliceosomes are massive RNA-protein macromolecular machines with >100 distinct components that assemble onto nascent transcripts and are released...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.05.004
更新日期：2009-08-01 00:00:00
abstract：:Collective cell migration results from the establishment and maintenance of collective polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell migration depends on a reciprocal process between cell-intrinsic multicellular organization with leader-follower cell behavior and results in ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2015.06.003
更新日期：2015-09-01 00:00:00
abstract：:Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to control cell movement. Dynamic regulation of focal adhesions and reorganization of the associated actin cytoskeleton are crucial determinants of cell migration. There ar...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2004.03.011
更新日期：2004-05-01 00:00:00
abstract：:Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the cross...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2017.07.006
更新日期：2017-11-01 00:00:00
abstract：:The regulation of endothelial cell contacts is of central importance for the barrier function of the blood vessel wall and for the control of leukocyte extravasation. In addition, the plasticity of endothelial cell contacts is regulated during angiogenesis by growth factors, such as vascular endothelial growth factor ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.10.001
更新日期：2009-01-01 00:00:00
abstract：:Chloroplasts depend on the nucleus for much of their proteome. Consequently, strong transcriptional coordination exists between the genomes, which is attuned to the developmental and physiological needs of the organelle. Recent studies highlight that the post-translational modifier ubiquitin adds another layer to plas...
journal_title：Trends in cell biology
pub_type： 评论,杂志文章
doi：10.1016/j.tcb.2015.12.001
更新日期：2016-01-01 00:00:00
abstract：:Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2014.10.001
更新日期：2015-02-01 00:00:00
abstract：:The JAK-STAT signal-transduction pathway is utilized by a wide range of cytokines to regulate gene expression. Cytokines activate members of the JAK family o f protein tyrosine kinases, which in turn activate, by tyrosine phosphorylation, one or more STAT transcription factor family members. Activated STATs form dimer...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(96)10028-3
更新日期：1996-09-01 00:00:00
abstract：:Autophagy is a highly conserved process that allows cells, tissues and organs to survive onslaughts such as nutrient deprivation, inflammation, hypoxia and other stresses. The core component proteins that regulate autophagy are well known, and the formation of a double-membrane structure that encompasses cytosolic car...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2010.12.006
更新日期：2011-04-01 00:00:00
abstract：:While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.09.009
更新日期：2010-01-01 00:00:00
abstract：:Across the animal kingdom, color discrimination is achieved by comparing the outputs of photoreceptor cells (PRs) that have different spectral sensitivities. Much remains to be understood about how the pattern of these different PRs is generated and maintained. The Drosophila eye has long provided a beautiful system f...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2004.09.007
更新日期：2004-10-01 00:00:00
abstract：:Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoev...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2018.08.005
更新日期：2019-01-01 00:00:00
abstract：:RNA-binding proteins are involved in various aspects of RNA metabolism such as processing, translational control, stabilization, localization and transport. Many of these proteins bind several RNA targets and have multiple functions. In this review we focus on RNA-binding proteins that are implicated in RNA transport ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(02)02357-7
更新日期：2002-10-01 00:00:00
abstract：:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization o...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(01)02005-0
更新日期：2001-06-01 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta) regulates cell proliferation, differentiation and apoptosis, and TGF-beta-related proteins have key roles in development, tissue homeostasis and disease. Upon binding to their cell surface receptors, TGF-beta family proteins signal through Smads to induce changes in gene expr...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.05.008
更新日期：2009-08-01 00:00:00
abstract：:Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to th...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2012.01.004
更新日期：2012-04-01 00:00:00
abstract：:Cellular membranes differ in their molecular organisation, shape, and dynamics. Knowing how these properties of membrane architecture relate to the presence and function of specific membrane components is fundamental for understanding membrane-associated cellular processes. Correlative light and electron microscopy (C...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.04.003
更新日期：2020-07-01 00:00:00
abstract：:The E2F family of transcriptional regulators sits at the center of cell cycle gene expression and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by the retinoblastoma family of proteins is well established, much less is known about their regulation by ubiquitin pathways. Recent studies pla...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.05.002
更新日期：2020-08-01 00:00:00
abstract：:Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and t...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2020.11.009
更新日期：2020-12-26 00:00:00
abstract：:Stem cell niches are specialized microenvironments where pluripotent cells are maintained to provide undifferentiated cells for the formation of new tissues and organs. The balance between stem cell maintenance within the niche and differentiation of cells that exit it is regulated by local cell-cell communication, to...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2007.06.002
更新日期：2007-08-01 00:00:00
abstract：:The basement membrane (BM), a specialized network of extracellular matrix macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells. During development, immune surveillance and disease states ranging from cancer to fibrosis, host cells penetrate the BM by engaging tissue-invasive programs, the ide...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.08.007
更新日期：2008-11-01 00:00:00
abstract：:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-01 00:00:00
abstract：:Protists have evolved a myriad of highly specialized cytoskeletal organelles that expand known functional capacities of microtubule (MT) polymers. One such innovation - the ventral disc - is a cup-shaped MT organelle that the parasite Giardia uses to attach to the small intestine of its host. The molecular mechanisms ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2017.10.007
更新日期：2018-02-01 00:00:00
abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/s0962-8924(01)02182-1
更新日期：2001-11-01 00:00:00
