Abstract：
:Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and the genome at its interior. Actin-dependent nucleus displacement was first described a decade ago. We are now gaining a more detailed understanding of its mechanisms, as well as new roles for actin during mitosis and meiosis, for gene expression, and in the cell's response to mechanical stimuli. Here we review these recent developments, the actin-binding proteins involved, the tissue specificity of these mechanisms, and methods developed to reconstitute and study this interaction in vitro.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Davidson PM,Cadot Bdoi
10.1016/j.tcb.2020.11.009subject
Has Abstractpub_date
2020-12-26 00:00:00eissn
0962-8924issn
1879-3088pii
S0962-8924(20)30244-0pub_type
杂志文章,评审abstract：:The architecture of the interphase nucleus remains a treasure trove for explorers of the 3D folding of macromolecules, like DNA, and of their related functions. Only recently has there been insight into how transient interactions of the genome and its associated proteins, in space and time, facilitate transcription, r...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2016.04.011
更新日期：2016-07-01 00:00:00
abstract：:To better understand the physiology and acclimation capability of the cell, one of the great challenges of the future is to access the interior of a cell and unveil its chemical landscape (composition and distribution of elements and molecules). Chemical imaging has greatly improved in sensitivity and spatial resoluti...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.12.007
更新日期：2020-03-01 00:00:00
abstract：:The basement membrane (BM), a specialized network of extracellular matrix macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells. During development, immune surveillance and disease states ranging from cancer to fibrosis, host cells penetrate the BM by engaging tissue-invasive programs, the ide...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.08.007
更新日期：2008-11-01 00:00:00
abstract：:During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is invol...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2006.10.004
更新日期：2006-12-01 00:00:00
abstract：:Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely com...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(00)01739-6
更新日期：2000-05-01 00:00:00
abstract：:Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Sma...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2017.04.005
更新日期：2017-09-01 00:00:00
abstract：:Substantial progress has been made in recent years toward understanding the molecular mechanisms by which tumor cells, and the supporting stroma, degrade confining matrix during migration. Significant attention has been focused on understanding the biology of several dynamic and distinct, but remarkably related, cell ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.08.009
更新日期：2013-01-01 00:00:00
abstract：:Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2020.12.007
更新日期：2020-12-29 00:00:00
abstract：:Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.05.005
更新日期：2008-08-01 00:00:00
abstract：:'Secrete-and-sense cells' can communicate by secreting a signaling molecule while also producing a receptor that detects the molecule. The cell can potentially 'talk' to itself ('self-communication') or talk to neighboring cells with the same receptor ('neighbor communication'). The predominant forms of secrete-and-se...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2015.11.002
更新日期：2016-04-01 00:00:00
abstract：:The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/S0962-8924(97)01079-9
更新日期：1997-07-01 00:00:00
abstract：:The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2015.08.011
更新日期：2015-12-01 00:00:00
abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2016.08.005
更新日期：2016-11-01 00:00:00
abstract：:In response to stress, p53 initiates the transcriptional regulation of selected target genes and various cellular responses, including cell cycle arrest, apoptosis and senescence. Recent studies revealed two additional functions of p53 in the regulation of IGF-1/AKT/mTOR pathways and energy metabolism, contributing to...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2010.03.004
更新日期：2010-07-01 00:00:00
abstract：:Research performed over the past decade has transformed apoptosis from a distinctive form of cell death known only by its characteristic morphology and genomic destruction to an increasingly well understood cellular disassembly pathway remarkable for its complex and multifaceted regulation. Here, we summarize current ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(01)02173-0
更新日期：2001-12-01 00:00:00
abstract：:Cell polarization requires the segregation of the plasma membrane into domains of distinct protein composition. The Lethal giant larvae (Lgl) protein of Drosophila, initially identified as a tumor suppressor, establishes such domains by localizing specific proteins to specific regions of the plasma membrane. However, ...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2006.03.006
更新日期：2006-05-01 00:00:00
abstract：:Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in th...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.08.001
更新日期：2012-11-01 00:00:00
abstract：:Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway a...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(97)01209-9
更新日期：1998-04-01 00:00:00
abstract：:Bidirectional microtubule-dependent organelle transport in melanophores is regulated by cAMP through organelle-bound protein kinase A (PKA); however, the mechanisms responsible for this regulation are unknown. A recent study by Gelfand and colleagues demonstrates that, in addition to PKA, transport is regulated by the...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2005.06.002
更新日期：2005-08-01 00:00:00
abstract：:Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2018.06.008
更新日期：2018-11-01 00:00:00
abstract：:Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocyto...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0962-8924(02)02399-1
更新日期：2002-12-01 00:00:00
abstract：:It is widely believed that calorie restriction (CR) can extend the lifespan of model organisms and protect against aging-related diseases. A potential CR mimetic is resveratrol, which may have beneficial effects against numerous diseases such as type 2 diabetes, cardiovascular diseases, and cancer in tissue culture an...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.07.004
更新日期：2012-10-01 00:00:00
abstract：:In higher eukaryotes, the vast majority of protein-coding genes contain introns that must be removed from precursor mRNA (pre-mRNA) with great precision by the spliceosome. Spliceosomes are massive RNA-protein macromolecular machines with >100 distinct components that assemble onto nascent transcripts and are released...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.05.004
更新日期：2009-08-01 00:00:00
abstract：:Autophagy is a highly conserved process that allows cells, tissues and organs to survive onslaughts such as nutrient deprivation, inflammation, hypoxia and other stresses. The core component proteins that regulate autophagy are well known, and the formation of a double-membrane structure that encompasses cytosolic car...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2010.12.006
更新日期：2011-04-01 00:00:00
abstract：:Sustained pro-proliferative signaling is one of the hallmarks of cancer. Although it is generally understood that the oncogenic signaling pathways are overactivated, or at least abnormally activated, in cancer cells, important mechanistic details of such abnormal activation remain unresolved. Among these details are s...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2019.08.005
更新日期：2019-11-01 00:00:00
abstract：:Polarised vesicle trafficking has been suggested to regulate cell migration. Understanding how this takes place has been complicated by the use of disparate assays and cellular models. Although polarised trafficking does occur in cell motility it is not clear which pathways are involved. We propose a model for migrati...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2009.11.006
更新日期：2010-02-01 00:00:00
abstract：:Until recently, the cell biology of mammalian muscle repair following damage appeared to be completely different from the formation of new muscles in regenerated appendages of Amphibia. Mammalian muscle repair occurs through the mobilization of muscle satellite cells, whereas the new muscle in amphibian appendage rege...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2006.04.007
更新日期：2006-06-01 00:00:00
abstract：:Many organisms stringently regulate the number, volume and enzymatic content of peroxisomes (and other organelles). Understanding this regulation requires knowledge of how organelles are assembled and selectively destroyed in response to metabolic cues. In the past decade, considerable progress has been achieved in th...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2004.07.014
更新日期：2004-09-01 00:00:00
abstract：:The role o f iron in cell division, cell death and human disease has recently gained increased attention. The best studied process for iron uptake into mammalian cells involves traps ferrin and its receptor. This review discusses evidence supporting the existence of other routes by which iron can enter mammalian cells...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(96)10019-2
更新日期：1996-06-01 00:00:00
abstract：:Meiosis is a specialized type of cell division leading to the production of gametes. During meiotic prophase I, homologous chromosomes interact with each other and form bivalents (pairs of homologous chromosomes). Three major meiotic processes--chromosome pairing, synapsis and recombination--are involved in the format...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2005.10.005
更新日期：2005-12-01 00:00:00
