Abstract:
:During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Nankoe SR,Sever Sdoi
10.1016/j.tcb.2006.10.004subject
Has Abstractpub_date
2006-12-01 00:00:00pages
607-9issue
12eissn
0962-8924issn
1879-3088pii
S0962-8924(06)00274-1journal_volume
16pub_type
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