Abstract：
:Recent work has revealed that mitochondria and chloroplasts are subject to direct control by the ubiquitin-proteasome system (UPS). Ubiquitin E3 ligases are present at the outer membrane of both organelles where they mediate ubiquitination and turnover of other organellar proteins. Both organelles exhibit remarkable structural dynamism and UPS control is particularly concerned with these properties. In mitochondria, the UPS targets factors involved in organellar fission and fusion, with significant impacts upon organellar morphology, mitophagy, and apoptosis. In chloroplasts (and other plastids), the UPS targets components of the protein import machinery, facilitating reorganization of the organellar proteome to determine organellar development and functions. Acquisition of such regulatory control during evolution is perhaps linked to the dynamic characteristics of the two organelles, which are not paralleled in their prokaryotic relatives. Here we discuss our current understanding of the role of the UPS in the regulation of endosymbiotic organelles.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Ling Q,Jarvis Pdoi
10.1016/j.tcb.2013.04.008subject
Has Abstractpub_date
2013-08-01 00:00:00pages
399-408issue
8eissn
0962-8924issn
1879-3088pii
S0962-8924(13)00064-0journal_volume
23pub_type
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