Abstract：
:Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a good model for studying the role of the matrix metalloproteases (MMPs) not only as simple effectors of ECM degradation but also as regulators of active signal-inducers for the initiation of endochondral ossification. The daunting task of elucidating their specific role during endochondral ossification has been facilitated by the development of mice deficient for various members of this family. Here, we discuss the ECM and its remodeling as one level of molecular regulation for the process of endochondral ossification, with special attention to the MMPs.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Ortega N,Behonick DJ,Werb Zdoi
10.1016/j.tcb.2003.12.003subject
Has Abstractpub_date
2004-02-01 00:00:00pages
86-93issue
2eissn
0962-8924issn
1879-3088pii
S0962892403003027journal_volume
14pub_type
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