Abstract：
:It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it became clear that these dynamic processes are also critical to regulating cell death, mitophagy, and organelle distribution. Now, studies suggest that prominent changes occur in mitochondrial dynamics in a broad array of neurodegenerative diseases, and there is substantial evidence suggesting a key role in disease pathogenesis because neurons are among the most energy-consuming cell types and have a highly developed cell shape. Here, we review the recent findings on mitochondrial dynamics in neurodegeneration.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Itoh K,Nakamura K,Iijima M,Sesaki Hdoi
10.1016/j.tcb.2012.10.006subject
Has Abstractpub_date
2013-02-01 00:00:00pages
64-71issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(12)00184-5journal_volume
23pub_type
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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