Abstract：
:Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids to lag on the mitotic spindle and hindering their timely segregation. Recent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal instability in cancer cells have underlined the importance of studying merotely. Here, we highlight recent progress in our understanding of how cells prevent and correct merotelic kinetochore attachments.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Gregan J,Polakova S,Zhang L,Tolić-Nørrelykke IM,Cimini Ddoi
10.1016/j.tcb.2011.01.003subject
Has Abstractpub_date
2011-06-01 00:00:00pages
374-81issue
6eissn
0962-8924issn
1879-3088pii
S0962-8924(11)00004-3journal_volume
21pub_type
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