Abstract:
:The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and severing actin filaments. Genetic and cell-biological studies have shown that an ADF/cofilin is required to drive the high turnover of the actin cytoskeleton observed in vivo. The activity of ADF/cofilin is regulated by a variety of mechanisms, including specific phosphorylation and dephosphorylation. This review addresses aspects of ADF/cofilin structure, dynamics, regulation and function.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Bamburg JR,McGough A,Ono Sdoi
10.1016/s0962-8924(99)01619-0subject
Has Abstractpub_date
1999-09-01 00:00:00pages
364-70issue
9eissn
0962-8924issn
1879-3088pii
S0962-8924(99)01619-0journal_volume
9pub_type
杂志文章,评审abstract::The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors...
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