Abstract:
:Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. This form of iron-dependent cell death is genetically, biochemically, and morphologically distinct from other cell death modalities, including apoptosis, unregulated necrosis, and necroptosis. Ferroptosis is regulated by specific pathways and is involved in diverse biological contexts. Here we summarize the discovery of ferroptosis, the mechanism of ferroptosis regulation, and its increasingly appreciated relevance to both normal and pathological physiology.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Yang WS,Stockwell BRdoi
10.1016/j.tcb.2015.10.014subject
Has Abstractpub_date
2016-03-01 00:00:00pages
165-176issue
3eissn
0962-8924issn
1879-3088pii
S0962-8924(15)00216-0journal_volume
26pub_type
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journal_title:Trends in cell biology
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journal_title:Trends in cell biology
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