Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease.

abstract：:Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context...

journal_title：Trends in cell biology

authors： Fafián-Labora JA,O'Loghlen A

更新日期：2020-08-01 00:00:00

abstract：:The endoplasmic reticulum (ER) contains a variety of specialized proteins that interact with secretory proteins and facilitate their uptake into transport vesicles destined for the Golgi apparatus. These accessory proteins might induce and/or stabilize a conformation that is required for secretion competence or they m...

journal_title：Trends in cell biology

authors： Herrmann JM,Malkus P,Schekman R

更新日期：1999-01-01 00:00:00

abstract：:Genetic instability contributes to the origin of cancer as well as to the ability of cancer cells to become resistant to various therapies. Because of this, cytotoxic rather than cytostatic therapies might be most effective against this disease. Many oncogenes and tumor suppressors mediate their effects by interfering...

journal_title：Trends in cell biology

authors： Huang P,Oliff A

更新日期：2001-08-01 00:00:00

abstract：:Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational models, comprising quantitative data on the interacting molecular participants in these events, provide a means for applying the scientifi...

journal_title：Trends in cell biology

authors： Slepchenko BM,Schaff JC,Macara I,Loew LM

更新日期：2003-11-01 00:00:00

abstract：:The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counte...

journal_title：Trends in cell biology

authors： Torraca V,Mostowy S

更新日期：2018-02-01 00:00:00

abstract：:Luke and colleagues have recently attributed a new role to a member of the serpin superfamily of serine proteinase inhibitors. They have used Caenorhabditis elegans to show that an intracellular serpin is crucial for maintaining lysosomal integrity. We examine the role of this firewall in preventing necrosis and attem...

journal_title：Trends in cell biology

authors： Marciniak SJ,Lomas DA

更新日期：2008-02-01 00:00:00

abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...

journal_title：Trends in cell biology

authors： Goldstein B,King N

更新日期：2016-11-01 00:00:00

abstract：:Our present understanding of intracellular protein degradation developed from an attempt to understand the metabolic stability of proteins in cells. With the unravelling of its complex biochemical machinery has come a realization that protein degradation plays an important role in the most crucial events in the cell c...

journal_title：Trends in cell biology

authors： Kirschner M

更新日期：1999-12-01 00:00:00

abstract：:RNA-binding proteins are involved in various aspects of RNA metabolism such as processing, translational control, stabilization, localization and transport. Many of these proteins bind several RNA targets and have multiple functions. In this review we focus on RNA-binding proteins that are implicated in RNA transport ...

journal_title：Trends in cell biology

authors： Farina KL,Singer RH

更新日期：2002-10-01 00:00:00

abstract：:Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2). This has major implications for s...

journal_title：Trends in cell biology

authors： Temple MD,Perrone GG,Dawes IW

更新日期：2005-06-01 00:00:00

abstract：:Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to ...

journal_title：Trends in cell biology

authors： Rajyaguru P,Parker R

更新日期：2009-01-01 00:00:00

abstract：:The glycoproteome, the ensemble of glycans and their carrier proteins, plays major roles in multicellular life by regulating cell interactions with their environment. How information is encoded into the glycome, in other words how glycosylation is modulated in response to signals, remains largely unclear. Glycosylatio...

journal_title：Trends in cell biology

authors： Bard F,Chia J

更新日期：2016-05-01 00:00:00

abstract：:Until recently, the cell biology of mammalian muscle repair following damage appeared to be completely different from the formation of new muscles in regenerated appendages of Amphibia. Mammalian muscle repair occurs through the mobilization of muscle satellite cells, whereas the new muscle in amphibian appendage rege...

journal_title：Trends in cell biology

authors： Slack JM

更新日期：2006-06-01 00:00:00

abstract：:The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to p...

journal_title：Trends in cell biology

authors： Wang F,Higgins JM

更新日期：2013-04-01 00:00:00

abstract：:The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...

journal_title：Trends in cell biology

authors： Sawarkar R,Paro R

更新日期：2013-04-01 00:00:00

abstract：:Microtubules are composed predominantly of two related proteins: alpha- and beta-tubulin. These proteins form the tubulin heterodimer, which is the basic building block of microtubules. Surprisingly, recent molecular genetic studies have revealed the existence of gamma-tubulin, a new member of the tubulin family. Like...

journal_title：Trends in cell biology

authors： Oakley BR

更新日期：1992-01-01 00:00:00

abstract：:The architecture of the interphase nucleus remains a treasure trove for explorers of the 3D folding of macromolecules, like DNA, and of their related functions. Only recently has there been insight into how transient interactions of the genome and its associated proteins, in space and time, facilitate transcription, r...

journal_title：Trends in cell biology

authors： Gasser SM

更新日期：2016-07-01 00:00:00

abstract：:The directional migration of cells within multicellular organisms is governed by gradients of both chemical attractants and repellents in diverse processes, including leukocyte trafficking and neuronal pathfinding in vivo. These complex extracellular environments direct the orchestrated bidirectional trafficking of le...

journal_title：Trends in cell biology

authors： Huttenlocher A,Poznansky MC

更新日期：2008-06-01 00:00:00

abstract：:Recent characterization of the major protein-targeting systems in both yeast and mammalian cells has provided detailed descriptions of how cellular transport processes operate. Increasingly, however, novel protein-sorting mechanisms are being uncovered. These newly discovered 'alternative' mechanisms of protein sortin...

journal_title：Trends in cell biology

authors： Klionsky DJ

更新日期：1997-06-01 00:00:00

abstract：:Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling. ...

journal_title：Trends in cell biology

authors： Follain G,Goetz JG

更新日期：2018-07-01 00:00:00

abstract：:Autophagy is a highly conserved process that allows cells, tissues and organs to survive onslaughts such as nutrient deprivation, inflammation, hypoxia and other stresses. The core component proteins that regulate autophagy are well known, and the formation of a double-membrane structure that encompasses cytosolic car...

journal_title：Trends in cell biology

authors： McEwan DG,Dikic I

更新日期：2011-04-01 00:00:00

abstract：:The nucleus is a spatially organized compartment. The most obvious way in which this is achieved is at the level of chromosomes. The positioning of chromosomes with respect to nuclear landmarks and with respect to each other is both non-random and cell-type specific. This suggests that cells possess molecular mechanis...

journal_title：Trends in cell biology

authors： Meldi L,Brickner JH

更新日期：2011-12-01 00:00:00

abstract：:Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is ...

journal_title：Trends in cell biology

authors： Amson R,Pece S,Marine JC,Di Fiore PP,Telerman A

更新日期：2013-01-01 00:00:00

abstract：:Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...

journal_title：Trends in cell biology

authors： Joshi U,Houwman JA,van der Sluijs P

更新日期：2018-10-01 00:00:00

abstract：:Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate...

journal_title：Trends in cell biology

authors： Traylor-Knowles N,Palumbi SR

更新日期：2014-05-01 00:00:00

abstract：:Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The mechanisms responsible for sorting, transporting, and ultimately delivering membranes and cargo to lysosomes through fusion have been intensel...

journal_title：Trends in cell biology

authors： Saffi GT,Botelho RJ

更新日期：2019-08-01 00:00:00

abstract：:Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, ...

journal_title：Trends in cell biology

authors： Otani T,Furuse M

更新日期：2020-10-01 00:00:00

abstract：:The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural ...

journal_title：Trends in cell biology

authors： Machamer CE

更新日期：2003-06-01 00:00:00

abstract：:Somatic stem cells maintain tissue homeostasis by organizing themselves in such a way that they can maintain proliferative output while simultaneously protecting themselves from DNA damage that may lead to oncogenic transformation. There is considerable debate about how such stem cell compartments are organized. Burge...

journal_title：Trends in cell biology

authors： Yousefi M,Li L,Lengner CJ

更新日期：2017-10-01 00:00:00

abstract：:Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the cross...

journal_title：Trends in cell biology

authors： Thelen AM,Zoncu R

更新日期：2017-11-01 00:00:00