Abstract：
:Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the crossroads of this network due to its ability to process and sort exogenous and endogenous lipids. The lipid-sorting function of the lysosome is intimately connected to its recently discovered role as a metabolic command-and-control center, which relays multiple nutrient cues to the master growth regulator, mechanistic target of rapamycin complex (mTORC)1 kinase. In turn, mTORC1 potently drives anabolic processes, including de novo lipid synthesis, while inhibiting lipid catabolism. Here, we describe the dual role of the lysosome in lipid transport and biogenesis, and we discuss how integration of these two processes may play important roles both in normal physiology and in disease.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Thelen AM,Zoncu Rdoi
10.1016/j.tcb.2017.07.006subject
Has Abstractpub_date
2017-11-01 00:00:00pages
833-850issue
11eissn
0962-8924issn
1879-3088pii
S0962-8924(17)30124-1journal_volume
27pub_type
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