Abstract：
:Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies have argued that autophagy is either repressed or highly active during mitosis. Recent studies have shown that autophagy initiation is repressed, and cap-dependent mRNA translation is maintained during mitosis despite mTORC1 activity being repressed. This is achieved in large part by a switch from mTORC1- to cyclin-dependent kinase 1 (CDK1)-mediated regulation. Here, we review the history and recent advances and seek to present a unifying model to inform the future study of autophagy and mTORC1 during mitosis.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Odle RI,Florey O,Ktistakis NT,Cook SJdoi
10.1016/j.tcb.2020.11.001subject
Has Abstractpub_date
2021-02-01 00:00:00pages
95-107issue
2eissn
0962-8924issn
1879-3088pii
S0962-8924(20)30226-9journal_volume
31pub_type
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