Regulation of endocytic traffic by rho family GTPases.

abstract：:Endosomal protein sorting governs the fate of many physiologically important proteins involved in a panoply of cellular functions. Recent discoveries have revealed a vital role for endosomally localised branched actin patches in facilitating protein sorting. The formation of the actin patches has been shown to require...

journal_title：Trends in cell biology

authors： Seaman MN,Gautreau A,Billadeau DD

更新日期：2013-11-01 00:00:00

abstract：:Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merote...

journal_title：Trends in cell biology

authors： Gregan J,Polakova S,Zhang L,Tolić-Nørrelykke IM,Cimini D

更新日期：2011-06-01 00:00:00

abstract：:During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is invol...

journal_title：Trends in cell biology

authors： Nankoe SR,Sever S

更新日期：2006-12-01 00:00:00

abstract：:Genetic instability contributes to the origin of cancer as well as to the ability of cancer cells to become resistant to various therapies. Because of this, cytotoxic rather than cytostatic therapies might be most effective against this disease. Many oncogenes and tumor suppressors mediate their effects by interfering...

journal_title：Trends in cell biology

authors： Huang P,Oliff A

更新日期：2001-08-01 00:00:00

abstract：:Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. Ho...

journal_title：Trends in cell biology

authors： Goldstein B,King N

更新日期：2016-11-01 00:00:00

abstract：:It is widely believed that calorie restriction (CR) can extend the lifespan of model organisms and protect against aging-related diseases. A potential CR mimetic is resveratrol, which may have beneficial effects against numerous diseases such as type 2 diabetes, cardiovascular diseases, and cancer in tissue culture an...

journal_title：Trends in cell biology

authors： Chung JH,Manganiello V,Dyck JR

更新日期：2012-10-01 00:00:00

abstract：:Gene editing in zebrafish has begun to reveal discordance between mutant phenotypes and those associated with knockdown via morpholino oligonucleotides (MOs). These studies suggest that MOs should not be used as a standalone tool and underscore the need for guidelines that require defined mutants to assess gene functi...

journal_title：Trends in cell biology

authors： Lawson ND

更新日期：2016-02-01 00:00:00

abstract：:Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, ...

journal_title：Trends in cell biology

authors： Otani T,Furuse M

更新日期：2020-10-01 00:00:00

abstract：:Fluorescent proteins have revolutionized biomedical research as they are easy to use for protein tagging, cope without fixation or permeabilization, and thus, enable live cell imaging in various models. Current methods allow easy and quick integration of fluorescent markers to endogenous genes of interest. In this rev...

journal_title：Trends in cell biology

authors： Bukhari H,Müller T

更新日期：2019-11-01 00:00:00

abstract：:Membrane trafficking pathways function to sort and transport cargoes to various intracellular compartments and to the plasma membrane. This allows precise spatiotemporal control of processes such as signal transduction, which in turn is crucial for complex cell functions such as cell division, migration and polarity. ...

journal_title：Trends in cell biology

authors： Wickström SA,Fässler R

更新日期：2011-05-01 00:00:00

abstract：:Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2). This has major implications for s...

journal_title：Trends in cell biology

authors： Temple MD,Perrone GG,Dawes IW

更新日期：2005-06-01 00:00:00

abstract：:Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway a...

journal_title：Trends in cell biology

authors： Johannes L,Goud B

更新日期：1998-04-01 00:00:00

abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...

journal_title：Trends in cell biology

authors： Wilson EK

更新日期：2001-11-01 00:00:00

abstract：:Leukocytes are key cellular components of innate immunity. These phagocytic cells respond to bacteria at sites of infection through chemotactic sensing and directed motility regulated by Rho GTPases. The development of sensitive probes of Rho GTPase dynamics has provided insights into the temporal and spatial aspects ...

journal_title：Trends in cell biology

authors： Bokoch GM

更新日期：2005-03-01 00:00:00

abstract：:The synthesis, assembly and organisation of structural and motor proteins during muscle formation requires temporal and spatial control directed by specialized chaperones. For example, alphaB-crystallin, GimC and TRiC facilitate the assembly of sarcomeric proteins such as desmin and actin. Recent studies have demonstr...

journal_title：Trends in cell biology

authors： Kim J,Löwe T,Hoppe T

更新日期：2008-06-01 00:00:00

abstract：:A major quest in cell biology is to understand the molecular mechanisms underlying the high plasticity of the microtubule network at different stages of the cell cycle, and during and after differentiation. Initial reports described the centrosomal localization of proteins possessing transforming acidic coiled-coil (T...

journal_title：Trends in cell biology

authors： Peset I,Vernos I

更新日期：2008-08-01 00:00:00

abstract：:Chloroplasts depend on the nucleus for much of their proteome. Consequently, strong transcriptional coordination exists between the genomes, which is attuned to the developmental and physiological needs of the organelle. Recent studies highlight that the post-translational modifier ubiquitin adds another layer to plas...

journal_title：Trends in cell biology

authors： Hua Z,Vierstra RD

更新日期：2016-01-01 00:00:00

abstract：:The acid-secreting gastric parietal cell has a unique secretory membrane system. This membrane system exists in an inactive (non-secreting) and an active (secreting) form. The current accepted model to explain the transformation events associated with the conversion of the non-secreting membrane to the secreting membr...

journal_title：Trends in cell biology

authors： Pettitt JM,van Driel IR,Toh BH,Gleeson PA

更新日期：1996-02-01 00:00:00

abstract：:A deeper understanding of the mechanisms of cell behavior is essential if we want to comprehend how an organism develops and functions. Changes in cellular processes, including the orientation of cell divisions, cell shape, polarity, differentiation and migration, account for tissue rearrangements during development a...

journal_title：Trends in cell biology

authors： Beis D,Stainier DY

更新日期：2006-02-01 00:00:00

abstract：:Neurodegenerative diseases are typically late-onset, progressive disorders that affect neural function and integrity. Although most attention has been focused on the genetic underpinnings of familial disease, mechanisms are likely to be shared with more predominant sporadic forms, which can be influenced by age, envir...

journal_title：Trends in cell biology

authors： Abe M,Bonini NM

更新日期：2013-01-01 00:00:00

abstract：:Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we...

journal_title：Trends in cell biology

authors： Nobre AR,Entenberg D,Wang Y,Condeelis J,Aguirre-Ghiso JA

更新日期：2018-11-01 00:00:00

abstract：:Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan. Other chondrodystrophies are te...

journal_title：Trends in cell biology

authors： Vertel BM

更新日期：1995-12-01 00:00:00

abstract：:Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...

journal_title：Trends in cell biology

authors： Ahmed K,Gerber DA,Cochet C

更新日期：2002-05-01 00:00:00

abstract：:Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Galpha subunits of heterotrimeric G proteins. Their ability to dampen signalling via Galphai-, Galphaq- and Galpha12/13-coupled pathways makes them crucial players in mediating the multitude...

journal_title：Trends in cell biology

authors： De Vries L,Gist Farquhar M

更新日期：1999-04-01 00:00:00

abstract：:Recent findings provide evidence for dynamic and highly regulated dual subcellular localization of catalase, a hydrogen peroxide (H2O2)-metabolizing enzyme, in peroxisomes and the cytosol. These data suggest a number of important implications for the field of oxidative stress biology. ...

journal_title：Trends in cell biology

authors： Fujiki Y,Bassik MC

更新日期：2021-01-06 00:00:00

abstract：:Polarised vesicle trafficking has been suggested to regulate cell migration. Understanding how this takes place has been complicated by the use of disparate assays and cellular models. Although polarised trafficking does occur in cell motility it is not clear which pathways are involved. We propose a model for migrati...

journal_title：Trends in cell biology

authors： Fletcher SJ,Rappoport JZ

更新日期：2010-02-01 00:00:00

abstract：:The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...

journal_title：Trends in cell biology

authors： Needleman D

更新日期：2015-12-01 00:00:00

abstract：:Every heart beat is not equal. As physiological demands of the cardiovascular system change, cardiac myocytes modulate contractile parameters including the rate and force of contraction. Adaptive responses require the sensing of biomechanical signals involving the interface between the contractile cytoskeleton (myofib...

journal_title：Trends in cell biology

authors： Miller MK,Granzier H,Ehler E,Gregorio CC

更新日期：2004-03-01 00:00:00

abstract：:Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support th...

journal_title：Trends in cell biology

authors： Bose S,Ramesh V,Locasale JW

更新日期：2019-09-01 00:00:00

abstract：:Why some genes are more popular than others remains an open question, but one example of this phenomenon involves the genes controlling planar cell polarity (PCP), the polarization of cells within a plane of a tissue. Indeed, the so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been extensive...

journal_title：Trends in cell biology

authors： Adler PN,Wallingford JB

更新日期：2017-05-01 00:00:00