Abstract：
:In higher eukaryotes, the vast majority of protein-coding genes contain introns that must be removed from precursor mRNA (pre-mRNA) with great precision by the spliceosome. Spliceosomes are massive RNA-protein macromolecular machines with >100 distinct components that assemble onto nascent transcripts and are released from the mRNA after splicing. A large and longstanding body of biochemical evidence indicates that the spliceosome is constructed de novo for each round of splicing in an ordered piece-by-piece stepwise assembly. More recently, exciting advances in intracellular imaging approaches are providing new clues to understand the dynamic organization of this and other multi-component molecular machines in the nucleus. The emerging data suggest that stochastic interactions between spliceosomal proteins originate intermediate complexes that localize in the close vicinity of active genes, thus contributing to increase the local availability of the individual pieces required for assembly of functional spliceosomes on newly synthesized pre-mRNA.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Rino J,Carmo-Fonseca Mdoi
10.1016/j.tcb.2009.05.004subject
Has Abstractpub_date
2009-08-01 00:00:00pages
375-84issue
8eissn
0962-8924issn
1879-3088pii
S0962-8924(09)00129-9journal_volume
19pub_type
杂志文章,评审abstract：:Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors...
journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2008.05.005
更新日期：2008-08-01 00:00:00
abstract：:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...
journal_title：Trends in cell biology
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abstract：:Asymmetric cell divisions are central to the generation of cell-fate diversity because factors that are present in a mother cell and distributed unequally at cell division can generate distinct daughters. The process o f asymmetric cell division can be described as consisting of three steps: setting up an asymmetric c...
journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(96)10035-0
更新日期：1996-10-01 00:00:00
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journal_title：Trends in cell biology
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更新日期：1997-12-01 00:00:00
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journal_title：Trends in cell biology
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更新日期：2019-02-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2009.03.005
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doi：10.1016/j.tcb.2017.05.002
更新日期：2017-08-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.tcb.2012.10.011
更新日期：2013-03-01 00:00:00
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journal_title：Trends in cell biology
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doi：10.1016/j.tcb.2015.12.004
更新日期：2016-05-01 00:00:00
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doi：10.1016/0962-8924(93)90033-w
更新日期：1993-12-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/j.tcb.2007.10.004
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-03-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章,评审
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/0962-8924(96)10019-2
更新日期：1996-06-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 传,历史文章,杂志文章,评审
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更新日期：1999-07-01 00:00:00
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abstract：:Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae - infoldings of the mitochondrial inner membrane (IM) - in different cells, tissues, bioenergetic and metabolic conditi...
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pub_type： 杂志文章
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更新日期：1992-03-01 00:00:00
