Abstract：
:After nearly four decades of investigation, the dynein motor is finally on the verge of revealing its inner secrets. This multisubunit ATPase participates in several important microtubule-based motilities in eukaryotic cells. Numerous recent articles have advanced the understanding of the dynein motor substructure and its mechanism of force production, revealing both similarities to other motors and some surprises. We are now in a position to summarize a basic blueprint for dynein. At its core, the motor is a ring-shaped object with two protruding levers: one engages cargo and might provide much of the force for movement, and the other interacts with the microtubule track. The activities of both levers are linked through nucleotide-dependent conformational changes in the ring.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Koonce MP,Samsó Mdoi
10.1016/j.tcb.2004.09.013subject
Has Abstractpub_date
2004-11-01 00:00:00pages
612-9issue
11eissn
0962-8924issn
1879-3088pii
S0962-8924(04)00264-8journal_volume
14pub_type
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