The control of ciliary beat frequency.

abstract：:Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates. Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different. I...

journal_title：Trends in cell biology

authors： D'Angiolella V,Esencay M,Pagano M

更新日期：2013-03-01 00:00:00

abstract：:In essence, the mitotic cell cycle in eukaryotes involves the duplication and separation of chromosomes, coupled to the process of dividing one cell into two. Cytokinesis is therefore the culmination of a series of events that were triggered during G1 phase, and brings the daughter cells back to the starting position ...

journal_title：Trends in cell biology

authors： den Boer BG,Murray JA

更新日期：2000-06-01 00:00:00

abstract：:Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway a...

journal_title：Trends in cell biology

authors： Johannes L,Goud B

更新日期：1998-04-01 00:00:00

abstract：:Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...

journal_title：Trends in cell biology

authors： Ahmed K,Gerber DA,Cochet C

更新日期：2002-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) regulates cell proliferation, differentiation and apoptosis, and TGF-beta-related proteins have key roles in development, tissue homeostasis and disease. Upon binding to their cell surface receptors, TGF-beta family proteins signal through Smads to induce changes in gene expr...

journal_title：Trends in cell biology

authors： Kang JS,Liu C,Derynck R

更新日期：2009-08-01 00:00:00

abstract：:Cellular organization of the cytoskeleton, assembly of intracellular signaling complexes and movement of membrane receptors into supramolecular activation complexes (SMACs) are crucial prerequisites for lymphocyte activation and function. Full T-cell activation requires costimulatory signals in addition to antigen-med...

journal_title：Trends in cell biology

authors： Krawczyk C,Penninger JM

更新日期：2001-05-01 00:00:00

abstract：:After nearly four decades of investigation, the dynein motor is finally on the verge of revealing its inner secrets. This multisubunit ATPase participates in several important microtubule-based motilities in eukaryotic cells. Numerous recent articles have advanced the understanding of the dynein motor substructure and...

journal_title：Trends in cell biology

authors： Koonce MP,Samsó M

更新日期：2004-11-01 00:00:00

abstract：:The endoplasmic reticulum (ER) contains a variety of specialized proteins that interact with secretory proteins and facilitate their uptake into transport vesicles destined for the Golgi apparatus. These accessory proteins might induce and/or stabilize a conformation that is required for secretion competence or they m...

journal_title：Trends in cell biology

authors： Herrmann JM,Malkus P,Schekman R

更新日期：1999-01-01 00:00:00

abstract：:Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play important roles in diverse biological processes. As a class, lncRNAs are generally enriched in the nucleus and, specifically, within the chromatin-associated fraction. Consistent with their localization, many lncRNAs have been implicated in ...

journal_title：Trends in cell biology

authors： Quinodoz S,Guttman M

更新日期：2014-11-01 00:00:00

abstract：:The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors...

journal_title：Trends in cell biology

authors： Linggi B,Carpenter G

更新日期：2006-12-01 00:00:00

abstract：:Every heart beat is not equal. As physiological demands of the cardiovascular system change, cardiac myocytes modulate contractile parameters including the rate and force of contraction. Adaptive responses require the sensing of biomechanical signals involving the interface between the contractile cytoskeleton (myofib...

journal_title：Trends in cell biology

authors： Miller MK,Granzier H,Ehler E,Gregorio CC

更新日期：2004-03-01 00:00:00

abstract：:Recent work has revealed that mitochondria and chloroplasts are subject to direct control by the ubiquitin-proteasome system (UPS). Ubiquitin E3 ligases are present at the outer membrane of both organelles where they mediate ubiquitination and turnover of other organellar proteins. Both organelles exhibit remarkable s...

journal_title：Trends in cell biology

authors： Ling Q,Jarvis P

更新日期：2013-08-01 00:00:00

abstract：:Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support th...

journal_title：Trends in cell biology

authors： Bose S,Ramesh V,Locasale JW

更新日期：2019-09-01 00:00:00

abstract：:The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...

journal_title：Trends in cell biology

authors： Storz P

更新日期：2007-01-01 00:00:00

abstract：:Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...

journal_title：Trends in cell biology

authors： Joshi U,Houwman JA,van der Sluijs P

更新日期：2018-10-01 00:00:00

abstract：:Synaptic junctions are highly specialized structures designed to promote the rapid and efficient transmission of signals from the presynaptic terminal to the postsynaptic membrane within the central nervous system. Proteins containing PDZ domains play a fundamental organizational role at both the pre- and postsynaptic...

journal_title：Trends in cell biology

authors： Garner CC,Nash J,Huganir RL

更新日期：2000-07-01 00:00:00

abstract：:Mucins are heavily glycosylated high molecular weight glycoproteins, which are involved in the protection and lubrication of luminal epithelial surfaces. Transmembrane mucins also engage in signal transduction, through extracellular domain-mediated ligand binding or by interacting with receptors for growth and differe...

journal_title：Trends in cell biology

authors： Singh PK,Hollingsworth MA

更新日期：2006-09-01 00:00:00

abstract：:Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signallin...

journal_title：Trends in cell biology

authors： Ellis S,Mellor H

更新日期：2000-03-01 00:00:00

abstract：:Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context...

journal_title：Trends in cell biology

authors： Fafián-Labora JA,O'Loghlen A

更新日期：2020-08-01 00:00:00

abstract：:It is well established that the target of rapamycin (TOR) protein kinase has pivotal roles in controlling cell functions (including protein synthesis, cell growth and cell proliferation) and is implicated in numerous human diseases. Mammalian TOR complex 1 (mTORC1) signalling is activated by hormones and growth factor...

journal_title：Trends in cell biology

authors： Wang X,Proud CG

更新日期：2009-06-01 00:00:00

abstract：:During the past 15 years mass spectrometry (MS)-based analyses have become established as the method of choice for direct protein identification and measurement. Owing to the remarkable improvements in the sensitivity and resolution of MS instruments, this technology has revolutionised the opportunities available for ...

journal_title：Trends in cell biology

authors： Ahmad Y,Lamond AI

更新日期：2014-04-01 00:00:00

abstract：:Structural plasticity of excitatory synapses is a vital component of neuronal development, synaptic plasticity and behavior, and its malfunction underlies many neurodevelopmental and psychiatric disorders. However, the molecular mechanisms that control dendritic spine morphogenesis have only recently emerged. We summa...

journal_title：Trends in cell biology

authors： Penzes P,Cahill ME,Jones KA,Srivastava DP

更新日期：2008-09-01 00:00:00

abstract：:The components of the bacterial division machinery assemble to form a dynamic ring at mid-cell that drives cytokinesis. The nature of most division proteins and their assembly pathway is known. Our knowledge about the biochemical activities and protein interactions of some key division elements, including those respon...

journal_title：Trends in cell biology

authors： Martos A,Jiménez M,Rivas G,Schwille P

更新日期：2012-12-01 00:00:00

abstract：:Electrophysiological studies have implicated voltage-gated proton channels in several specific cellular contexts. In neutrophils, they mediate charge compensation that is associated with the oxidative burst of phagocytosis. Molecular characterization of the hydrogen voltage-gated channel 1 (HVCN1) has enabled identifi...

journal_title：Trends in cell biology

authors： Capasso M,DeCoursey TE,Dyer MJ

更新日期：2011-01-01 00:00:00

abstract：:Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in m...

journal_title：Trends in cell biology

authors： Clarke PR,Zhang C

更新日期：2001-09-01 00:00:00

abstract：:Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a ...

journal_title：Trends in cell biology

authors： Ortega N,Behonick DJ,Werb Z

更新日期：2004-02-01 00:00:00

abstract：:A deeper understanding of the mechanisms of cell behavior is essential if we want to comprehend how an organism develops and functions. Changes in cellular processes, including the orientation of cell divisions, cell shape, polarity, differentiation and migration, account for tissue rearrangements during development a...

journal_title：Trends in cell biology

authors： Beis D,Stainier DY

更新日期：2006-02-01 00:00:00

abstract：:Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocyto...

journal_title：Trends in cell biology

authors： Marks DL,Pagano RE

更新日期：2002-12-01 00:00:00

abstract：:Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Sma...

journal_title：Trends in cell biology

authors： Budi EH,Duan D,Derynck R

更新日期：2017-09-01 00:00:00

abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...

journal_title：Trends in cell biology

authors： Wilson EK

更新日期：2001-11-01 00:00:00