Abstract:
:Every heart beat is not equal. As physiological demands of the cardiovascular system change, cardiac myocytes modulate contractile parameters including the rate and force of contraction. Adaptive responses require the sensing of biomechanical signals involving the interface between the contractile cytoskeleton (myofibrils) and the sarcolemma at specialized cell-cell junctions (intercalated discs) and cell-substrate adhesion complexes (costameres). Recent studies have shed insight into how protein complexes within cardiac myocytes sense biomechanical signals, processes required for normal adaptive or pathological responses. This new evidence suggests that complexes associated with the giant, myofibrillar protein titin sense myocyte stretch. Here, we discuss evidence supporting titin being an ideal biomechanical sensor.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Miller MK,Granzier H,Ehler E,Gregorio CCdoi
10.1016/j.tcb.2004.01.003subject
Has Abstractpub_date
2004-03-01 00:00:00pages
119-26issue
3eissn
0962-8924issn
1879-3088pii
S0962892404000224journal_volume
14pub_type
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