Intermediate filaments and lipoprotein cholesterol.

abstract：:Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to th...

journal_title：Trends in cell biology

authors： van der Laan M,Bohnert M,Wiedemann N,Pfanner N

更新日期：2012-04-01 00:00:00

abstract：:Eukaryotic cells contain numerous cytosolic and nuclear iron-sulfur (Fe/S) proteins that perform key functions in metabolic catalysis, iron regulation, protein translation, DNA synthesis, and DNA repair. Synthesis of Fe/S clusters and their insertion into apoproteins are essential for viability and are conserved in eu...

journal_title：Trends in cell biology

authors： Netz DJ,Mascarenhas J,Stehling O,Pierik AJ,Lill R

更新日期：2014-05-01 00:00:00

abstract：:Until recently, the cell biology of mammalian muscle repair following damage appeared to be completely different from the formation of new muscles in regenerated appendages of Amphibia. Mammalian muscle repair occurs through the mobilization of muscle satellite cells, whereas the new muscle in amphibian appendage rege...

journal_title：Trends in cell biology

authors： Slack JM

更新日期：2006-06-01 00:00:00

abstract：:Accurate spindle positioning is crucial for spatial control of cell division. During metazoan development, coordination between polarity cues and spindle position also ensures correct segregation of cell fate determinants. Converging evidence indicates that spindle positioning is achieved through interactions between ...

journal_title：Trends in cell biology

authors： Gönczy P

更新日期：2002-07-01 00:00:00

abstract：:The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...

journal_title：Trends in cell biology

authors： A R,Tyson JR,Stirling CJ

更新日期：1997-07-01 00:00:00

abstract：:Major advances in science are often tightly coupled with the development of new technology. The discovery of kinesin is an excellent example of this principle. The new technology was video-enhanced differential interference contrast light microscopy, which provided the enormous gain in image contrast needed to detect ...

journal_title：Trends in cell biology

authors： Salmon ED

更新日期：1995-04-01 00:00:00

abstract：:Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization o...

journal_title：Trends in cell biology

authors： Baas PW,Ahmad FJ

更新日期：2001-06-01 00:00:00

abstract：:The glycoproteome, the ensemble of glycans and their carrier proteins, plays major roles in multicellular life by regulating cell interactions with their environment. How information is encoded into the glycome, in other words how glycosylation is modulated in response to signals, remains largely unclear. Glycosylatio...

journal_title：Trends in cell biology

authors： Bard F,Chia J

更新日期：2016-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) regulates cell proliferation, differentiation and apoptosis, and TGF-beta-related proteins have key roles in development, tissue homeostasis and disease. Upon binding to their cell surface receptors, TGF-beta family proteins signal through Smads to induce changes in gene expr...

journal_title：Trends in cell biology

authors： Kang JS,Liu C,Derynck R

更新日期：2009-08-01 00:00:00

abstract：:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...

journal_title：Trends in cell biology

authors： Norton JD,Deed RW,Craggs G,Sablitzky F

更新日期：1998-02-01 00:00:00

abstract：:Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support th...

journal_title：Trends in cell biology

authors： Bose S,Ramesh V,Locasale JW

更新日期：2019-09-01 00:00:00

abstract：:Ciliary movement is powered by axonemal dynein. This article considers how a signal transduction cascade initiated at the cell membrane may activate outer dynein arms to change the velocity of microtubule sliding and the swimming speed of ciliated cells. For Paramecium, a critical event in the cascade is the cAMP-depe...

journal_title：Trends in cell biology

authors： Satir P,Barkalow K,Hamasaki T

更新日期：1993-11-01 00:00:00

abstract：:Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. This form of iron-dependent cell death is genetically, biochemically, and morp...

journal_title：Trends in cell biology

authors： Yang WS,Stockwell BR

更新日期：2016-03-01 00:00:00

abstract：:The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural ...

journal_title：Trends in cell biology

authors： Machamer CE

更新日期：2003-06-01 00:00:00

abstract：:Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2). This has major implications for s...

journal_title：Trends in cell biology

authors： Temple MD,Perrone GG,Dawes IW

更新日期：2005-06-01 00:00:00

abstract：:In higher eukaryotes, the vast majority of protein-coding genes contain introns that must be removed from precursor mRNA (pre-mRNA) with great precision by the spliceosome. Spliceosomes are massive RNA-protein macromolecular machines with >100 distinct components that assemble onto nascent transcripts and are released...

journal_title：Trends in cell biology

authors： Rino J,Carmo-Fonseca M

更新日期：2009-08-01 00:00:00

abstract：:Genetic instability contributes to the origin of cancer as well as to the ability of cancer cells to become resistant to various therapies. Because of this, cytotoxic rather than cytostatic therapies might be most effective against this disease. Many oncogenes and tumor suppressors mediate their effects by interfering...

journal_title：Trends in cell biology

authors： Huang P,Oliff A

更新日期：2001-08-01 00:00:00

abstract：:During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is invol...

journal_title：Trends in cell biology

authors： Nankoe SR,Sever S

更新日期：2006-12-01 00:00:00

abstract：:The vascular system matures during embryonic development to form a stable, well-organized tubular network. In vivo data have established that the extracellular matrix (ECM) is crucial in providing structural support to the vascular system. In vitro studies are defining the involvement of ECM-smooth-muscle cell signali...

journal_title：Trends in cell biology

authors： Brooke BS,Karnik SK,Li DY

更新日期：2003-01-01 00:00:00

abstract：:The components of the bacterial division machinery assemble to form a dynamic ring at mid-cell that drives cytokinesis. The nature of most division proteins and their assembly pathway is known. Our knowledge about the biochemical activities and protein interactions of some key division elements, including those respon...

journal_title：Trends in cell biology

authors： Martos A,Jiménez M,Rivas G,Schwille P

更新日期：2012-12-01 00:00:00

abstract：:Nuclear proteins are transported from the cytoplasm into the nucleus via nuclear envelope pore complexes (NPCs). At the molecular level, the mechanisms responsible for this transport remain obscure. However, it is known that, for many proteins, the process requires ATP and proceeds against formidable nucleocytoplasmic...

journal_title：Trends in cell biology

authors： Paine PL

更新日期：1993-10-01 00:00:00

abstract：:Land plants have developed highly sophisticated intercellular channels called plasmodesmata (PD) that mediate the cell-to-cell trafficking of signaling molecules, including non-cell autonomous proteins (NCAPs) and RNAs. Until recently, the biological significance of this position-dependent intercellular signaling syst...

journal_title：Trends in cell biology

authors： Lucas WJ,Ham BK,Kim JY

更新日期：2009-10-01 00:00:00

abstract：:The molecular mechanisms underlying targeted deposition of new membrane at the advancing furrow of a dividing cell have long been intriguing to cell biologists. Three recent studies have made use of Drosophila cellularization to explore current questions in this field. These findings indicate that both the secretory p...

journal_title：Trends in cell biology

authors： Strickland LI,Burgess DR

更新日期：2004-03-01 00:00:00

abstract：:Signaling through the highly conserved Wingless/Wnt pathway plays a crucial role in a diverse array of developmental processes, many of which depend upon the precise regulation of Wingless/Wnt signaling levels. Recent evidence has indicated that the intracellular trafficking of Wingless/Wnt signaling components can re...

journal_title：Trends in cell biology

authors： Seto ES,Bellen HJ

更新日期：2004-01-01 00:00:00

abstract：:Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and t...

journal_title：Trends in cell biology

authors： Davidson PM,Cadot B

更新日期：2020-12-26 00:00:00

abstract：:Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O2) and nutrient supply. Whereas normal cells modulate anabolic and catabolic pathways in response to changes in nutrient availability, cancer cells exhibit unregulated growth even under nutrient scarci...

journal_title：Trends in cell biology

authors： Ackerman D,Simon MC

更新日期：2014-08-01 00:00:00

abstract：:While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the...

journal_title：Trends in cell biology

authors： Barlow CA,Laishram RS,Anderson RA

更新日期：2010-01-01 00:00:00

abstract：:Diverse biological and developmental functions are mediated by signalling through the epidermal growth factor (EGF) receptor. In flies, many different mechanisms are used to control and restrict EGF-R signalling, including ligand processing, ligand variety (an inhibitor as well as activators), transcription and perhap...

journal_title：Trends in cell biology

authors： Wasserman JD,Freeman M

更新日期：1997-11-01 00:00:00

abstract：:In vitro cell biology has become an effective way to identify molecules responsible for membrane traffic. We have used this approach to study the assembly and budding of coated pits. So far our system has allowed us to identify a high-affinity binding site for the AP2 subunit on the inside surface of plasma membranes,...

journal_title：Trends in cell biology

authors： Anderson RG

更新日期：1993-06-01 00:00:00

abstract：:Recent findings provide evidence for dynamic and highly regulated dual subcellular localization of catalase, a hydrogen peroxide (H2O2)-metabolizing enzyme, in peroxisomes and the cytosol. These data suggest a number of important implications for the field of oxidative stress biology. ...

journal_title：Trends in cell biology

authors： Fujiki Y,Bassik MC

更新日期：2021-01-06 00:00:00