Abstract：
:Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to the identification of a large protein complex that is crucial for establishing inner-membrane architecture. This mitochondrial inner-membrane organizing system (MINOS) interacts with protein translocases of the outer membrane that are functionally connected to the endoplasmic reticulum (ER)-mitochondria encounter structure. Here, we propose that MINOS forms a central part of an ER-mitochondria organizing network (ERMIONE) that controls mitochondrial membrane architecture and biogenesis.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
van der Laan M,Bohnert M,Wiedemann N,Pfanner Ndoi
10.1016/j.tcb.2012.01.004subject
Has Abstractpub_date
2012-04-01 00:00:00pages
185-92issue
4eissn
0962-8924issn
1879-3088pii
S0962-8924(12)00015-3journal_volume
22pub_type
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