The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

abstract：:Research on the Golgi apparatus has resulted in major advances in understanding its structure and functions, but many important questions remain unanswered. The history of the Golgi apparatus has been marked by arguments and controversies, some of which have been resolved, whereas others are still ongoing. This articl...

journal_title：Trends in cell biology

authors： Farquhar MG,Palade GE

更新日期：1998-01-01 00:00:00

abstract：:The nuclear envelope (NE) breaks down reversibly and reassembles at mitosis. Two models of mitotic nuclear membrane disassembly and reformation have emerged from studies of NE dynamics in somatic cells and egg extracts. One model suggests that nuclear membranes fragment reversibly by vesiculation, producing NE-derived...

journal_title：Trends in cell biology

authors： Collas P,Courvalin JC

更新日期：2000-01-01 00:00:00

abstract：:The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intra...

journal_title：Trends in cell biology

authors： Andrews NW

更新日期：1995-03-01 00:00:00

abstract：:The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...

journal_title：Trends in cell biology

authors： Gardner RD,Burke DJ

更新日期：2000-04-01 00:00:00

abstract：:The transport of protein through the secretory pathway of eukaryotic cells relies on small vesicular carriers, which mediate the movement of cargo between different compartments. Here, Meir Aridor and Bill Balch summarize what is currently known about the role of the cytosolic coat complexes in directing the formation...

journal_title：Trends in cell biology

authors： Aridor M,Balch WE

更新日期：1996-08-01 00:00:00

abstract：:Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

journal_title：Trends in cell biology

authors： Cassereau J,Courdavault V,Nägerl UV

更新日期：2020-12-29 00:00:00

abstract：:Why some genes are more popular than others remains an open question, but one example of this phenomenon involves the genes controlling planar cell polarity (PCP), the polarization of cells within a plane of a tissue. Indeed, the so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been extensive...

journal_title：Trends in cell biology

authors： Adler PN,Wallingford JB

更新日期：2017-05-01 00:00:00

abstract：:Despite their small size and lack of obvious intracellular structures, bacteria have a complex and dynamic intracellular organization. Recent work has shown that many proteins, and even regions of the chromosome, are localized to specific subcellular regions that can change over time, sometimes extraordinarily fast. P...

journal_title：Trends in cell biology

authors： Jensen RB,Shapiro L

更新日期：2000-11-01 00:00:00

abstract：:Vascular barrier function is controlled at cell-cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms contro...

journal_title：Trends in cell biology

authors： Lagendijk AK,Yap AS,Hogan BM

更新日期：2018-03-01 00:00:00

abstract：:Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Sma...

journal_title：Trends in cell biology

authors： Budi EH,Duan D,Derynck R

更新日期：2017-09-01 00:00:00

abstract：:Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support th...

journal_title：Trends in cell biology

authors： Bose S,Ramesh V,Locasale JW

更新日期：2019-09-01 00:00:00

abstract：:Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...

journal_title：Trends in cell biology

authors： Wilson EK

更新日期：2001-11-01 00:00:00

abstract：:Chloroplasts have multiple suborganellar membranes. Correct and efficient translocation of chloroplast proteins from their site of synthesis into or across membranes to their functional compartments are fundamental processes. In recent years, several new components and regulatory mechanisms involved in chloroplast pro...

journal_title：Trends in cell biology

authors： Xu X,Ouyang M,Lu D,Zheng C,Zhang L

更新日期：2021-01-01 00:00:00

abstract：:Owing to the sessile nature of their lifestyle, plants have to respond to a wide range of signals, such as the force of the wind or the impedance of the soil, to entrain their development to prevailing environmental conditions. Indeed, mechanically responsive growth has been documented in plants for many years but new...

journal_title：Trends in cell biology

authors： Monshausen GB,Gilroy S

更新日期：2009-05-01 00:00:00

abstract：:Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

journal_title：Trends in cell biology

authors： Nicholson AL,Pasquinelli AE

更新日期：2019-03-01 00:00:00

abstract：:The cell surface receptor Fas/APO-1 and its ligand have recently been identified as important mediators of apoptosis. Both molecules are crucial for the maintenance of a sound immune system, and when defective they give rise to severe autoimmune disorders. Understanding the mechanism and regulation of Fas/APO-1-trigge...

journal_title：Trends in cell biology

authors： Schulze-Osthoff K

更新日期：1994-12-01 00:00:00

abstract：:Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discu...

journal_title：Trends in cell biology

authors： Wasserman S

更新日期：1998-03-01 00:00:00

abstract：:The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...

journal_title：Trends in cell biology

authors： Spencer WJ,Lewis TR,Pearring JN,Arshavsky VY

更新日期：2020-11-01 00:00:00

abstract：:Actin is an ancient and abundant protein with well-established roles in fundamental processes ranging from cell migration to membrane transport. Most eukaryotic cells also contain at least eight actin-related proteins (ARPs) that are, themselves, conserved between organisms as divergent as yeast and mammals. Although ...

journal_title：Trends in cell biology

authors： Blessing CA,Ugrinova GT,Goodson HV

更新日期：2004-08-01 00:00:00

abstract：:The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...

journal_title：Trends in cell biology

authors： Storz P

更新日期：2007-01-01 00:00:00

abstract：:There is a pronounced tendency among cell biologists to focus on qualitative aspects of cell physiology. The remarkable accomplishments of evolution in creating cells can only be fully appreciated, however, by combining this qualitative analysis with a quantitative assessment of cellular constituents and processes. He...

journal_title：Trends in cell biology

authors： Yewdell JW

更新日期：2001-07-01 00:00:00

abstract：:Electrophysiological studies have implicated voltage-gated proton channels in several specific cellular contexts. In neutrophils, they mediate charge compensation that is associated with the oxidative burst of phagocytosis. Molecular characterization of the hydrogen voltage-gated channel 1 (HVCN1) has enabled identifi...

journal_title：Trends in cell biology

authors： Capasso M,DeCoursey TE,Dyer MJ

更新日期：2011-01-01 00:00:00

abstract：:Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocyto...

journal_title：Trends in cell biology

authors： Marks DL,Pagano RE

更新日期：2002-12-01 00:00:00

abstract：:Several recent experimental findings support the hypothesis that apoptosis induced by human immune deficiency virus (HIV) is important in the pathogenesis of acquired immune deficiency syndrome (AIDS). Thus, one potential therapeutic strategy against AIDS may be to block the HIV-mediated apoptosis signal transduction ...

journal_title：Trends in cell biology

authors： Ameisen JC,Estaquier J,Idziorek T,De Bels F

更新日期：1995-01-01 00:00:00

abstract：:The organization of cells into interconnected structures such as animal tissues requires a sophisticated system directing receptors and adhesion proteins to the cell surface. The Rab11 small G proteins (Rab11a, b, and Rab25) of the Ras superfamily are master regulators of the surface expression of receptors and adhesi...

journal_title：Trends in cell biology

authors： Welz T,Wellbourne-Wood J,Kerkhoff E

更新日期：2014-07-01 00:00:00

abstract：:When starved, the fission yeast Schizosaccharomyces pombe responds by producing mating factors or pheromones that signal to cells of the opposite sex to initiate mating. Like its distant relative Saccharomyces cerevisiae, cells of the two mating types of S. pombe each produce a distinct pheromone that binds to recepto...

journal_title：Trends in cell biology

authors： Nielsen O

更新日期：1993-02-01 00:00:00

abstract：:The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counte...

journal_title：Trends in cell biology

authors： Torraca V,Mostowy S

更新日期：2018-02-01 00:00:00

abstract：:During the past 15 years mass spectrometry (MS)-based analyses have become established as the method of choice for direct protein identification and measurement. Owing to the remarkable improvements in the sensitivity and resolution of MS instruments, this technology has revolutionised the opportunities available for ...

journal_title：Trends in cell biology

authors： Ahmad Y,Lamond AI

更新日期：2014-04-01 00:00:00

abstract：:Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to ...

journal_title：Trends in cell biology

authors： Rajyaguru P,Parker R

更新日期：2009-01-01 00:00:00

abstract：:To better understand the physiology and acclimation capability of the cell, one of the great challenges of the future is to access the interior of a cell and unveil its chemical landscape (composition and distribution of elements and molecules). Chemical imaging has greatly improved in sensitivity and spatial resoluti...

journal_title：Trends in cell biology

authors： Decelle J,Veronesi G,Gallet B,Stryhanyuk H,Benettoni P,Schmidt M,Tucoulou R,Passarelli M,Bohic S,Clode P,Musat N

更新日期：2020-03-01 00:00:00