Abstract:
:The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. The checkpoint proteins interact in ways that are more complex than was originally envisioned. This review summarizes the evidence for two pathways of spindle-checkpoint regulation in budding yeast. We describe how the proteins are involved in these pathways and discuss the ways in which the spindle checkpoint inhibits the cell-cycle machinery.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Gardner RD,Burke DJdoi
10.1016/s0962-8924(00)01727-xsubject
Has Abstractpub_date
2000-04-01 00:00:00pages
154-8issue
4eissn
0962-8924issn
1879-3088pii
S0962-8924(00)01727-Xjournal_volume
10pub_type
杂志文章,评审abstract::Vascular barrier function is controlled at cell-cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms contro...
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