The Fas/APO-1 receptor and its deadly ligand.

abstract：:The actomyosin cytoskeleton is responsible for most force-driven processes in cells and tissues. How it assembles into the necessary structures at the right time and place is an important question. Here, we focus on molecular mechanisms of actomyosin regulation recently elucidated in animal models, and highlight sever...

journal_title：Trends in cell biology

authors： Agarwal P,Zaidel-Bar R

更新日期：2019-02-01 00:00:00

abstract：:Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate...

journal_title：Trends in cell biology

authors： Traylor-Knowles N,Palumbi SR

更新日期：2014-05-01 00:00:00

abstract：:To battle adverse internal and external conditions and maintain homeostasis, diploid organisms employ various cellular processes, such as proliferation and apoptosis. In some tissues, an alternative mechanism, endoreplication, is employed toward similar goals. Endoreplication is an evolutionarily conserved cell cycle ...

journal_title：Trends in cell biology

authors： Shu Z,Row S,Deng WM

更新日期：2018-06-01 00:00:00

abstract：:Polarised vesicle trafficking has been suggested to regulate cell migration. Understanding how this takes place has been complicated by the use of disparate assays and cellular models. Although polarised trafficking does occur in cell motility it is not clear which pathways are involved. We propose a model for migrati...

journal_title：Trends in cell biology

authors： Fletcher SJ,Rappoport JZ

更新日期：2010-02-01 00:00:00

abstract：:The function of caveolae is hotly debated. It now seems clear that caveolae are stable membrane domains that are kept in place by the actin cytoskeleton. However, this stability can be perturbed, leading to caveolar internalization. Caveolae are important in the regulation of various signaling processes, such as nitri...

journal_title：Trends in cell biology

authors： van Deurs B,Roepstorff K,Hommelgaard AM,Sandvig K

更新日期：2003-02-01 00:00:00

abstract：:The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicat...

journal_title：Trends in cell biology

authors： Guo W,Novick P

更新日期：2004-02-01 00:00:00

abstract：:Autophagy is a highly conserved process that allows cells, tissues and organs to survive onslaughts such as nutrient deprivation, inflammation, hypoxia and other stresses. The core component proteins that regulate autophagy are well known, and the formation of a double-membrane structure that encompasses cytosolic car...

journal_title：Trends in cell biology

authors： McEwan DG,Dikic I

更新日期：2011-04-01 00:00:00

abstract：:Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoev...

journal_title：Trends in cell biology

authors： Galluzzi L,Spranger S,Fuchs E,López-Soto A

更新日期：2019-01-01 00:00:00

abstract：:During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different...

journal_title：Trends in cell biology

authors： Sonneveld S,Verhagen BMP,Tanenbaum ME

更新日期：2020-08-01 00:00:00

abstract：:Transfer of proteins and lipids between the various membrane-bound subcellular compartments of the eukaryotic cell is mediated by transport vesicles. The development of cell-free assays has allowed rapid progress towards a molecular description of the formation, or budding, of these vesicles. This article reviews and ...

journal_title：Trends in cell biology

authors： Melançon P,Franzusoff A,Howell KE

更新日期：1991-12-01 00:00:00

abstract：:Plant seeds store nitrogen by accumulating storage proteins in protein bodies within various compartments of the endomembrane system. The prolamin storage proteins of some cereal species are normally retained and assembled into protein bodies within the ER. Yet, these proteins lack a C-terminal KDEL/HDEL signal, sugge...

journal_title：Trends in cell biology

authors： Galili G,Altschuler Y,Levanony H

更新日期：1993-12-01 00:00:00

abstract：:Cell biologists have used photobleaching to investigate the lateral mobility of fluorophores on the cell surface since the 1970s. Fusions of green fluorescent protein (GFP) to specific proteins extend photobleaching techniques to the investigation of protein dynamics within the cell, leading to renewed interest in pho...

journal_title：Trends in cell biology

authors： White J,Stelzer E

更新日期：1999-02-01 00:00:00

abstract：:The ability of cells to utilize cholesterol derived from lipoprotein is important in plasma membrane biosynthesis, steroidogenesis and the regulation of sterol synthesis. While the endocytosis of lipoprotein-derived cholesterol has been well characterized, the subsequent events that mediate its post-lysosomal intracel...

journal_title：Trends in cell biology

authors： Evans RM

更新日期：1994-05-01 00:00:00

abstract：:The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regula...

journal_title：Trends in cell biology

authors： Kamenz J,Hauf S

更新日期：2017-01-01 00:00:00

abstract：:Cyclin-dependent kinase 2 (CDK2) regulates diverse aspects of the mammalian cell cycle. Most cancer cells contain mutations in the pathways that control CDK2, and CDK2 activity has received much attention as a target for cancer therapy. However, a recent report demonstrating that some cancer cells can proliferate with...

journal_title：Trends in cell biology

authors： Grim JE,Clurman BE

更新日期：2003-08-01 00:00:00

abstract：:Why some genes are more popular than others remains an open question, but one example of this phenomenon involves the genes controlling planar cell polarity (PCP), the polarization of cells within a plane of a tissue. Indeed, the so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been extensive...

journal_title：Trends in cell biology

authors： Adler PN,Wallingford JB

更新日期：2017-05-01 00:00:00

abstract：:The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...

journal_title：Trends in cell biology

authors： Sawarkar R,Paro R

更新日期：2013-04-01 00:00:00

abstract：:In higher eukaryotes, the vast majority of protein-coding genes contain introns that must be removed from precursor mRNA (pre-mRNA) with great precision by the spliceosome. Spliceosomes are massive RNA-protein macromolecular machines with >100 distinct components that assemble onto nascent transcripts and are released...

journal_title：Trends in cell biology

authors： Rino J,Carmo-Fonseca M

更新日期：2009-08-01 00:00:00

abstract：:Damage to any tissue triggers a cascade of events that leads to rapid repair of the wound - if the tissue is skin, then repair involves re-epithelialization, formation of granulation tissue and contraction of underlying wound connective tissues. This concerted effort by the wounded cell layers is accompanied by, and m...

journal_title：Trends in cell biology

authors： Martin P,Leibovich SJ

更新日期：2005-11-01 00:00:00

abstract：:Caveolae are ampullate (flask-shaped) invaginations that are abundant in the plasma membrane of many mammalian cell types. Although caveolae are implicated in a wide range of processes including endothelial transcytosis, lipid homeostasis and cellular signalling, a detailed molecular picture of many aspects of their f...

journal_title：Trends in cell biology

authors： Hansen CG,Nichols BJ

更新日期：2010-04-01 00:00:00

abstract：:Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and t...

journal_title：Trends in cell biology

authors： Davidson PM,Cadot B

更新日期：2020-12-26 00:00:00

abstract：:Microbiology and cell biology both involve the study of cells, albeit at different levels of complexity and scale. Interactions between both fields during the past 25 years have led to major conceptual and technological advances that have reshaped the whole biology landscape and its biomedical applications. ...

journal_title：Trends in cell biology

authors： Pizarro-Cerdá J,Cossart P

更新日期：2016-07-01 00:00:00

abstract：:Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunct...

journal_title：Trends in cell biology

authors： Slaats GG,Giles RH

更新日期：2015-06-01 00:00:00

abstract：:Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...

journal_title：Trends in cell biology

authors： Ahmed K,Gerber DA,Cochet C

更新日期：2002-05-01 00:00:00

abstract：:Nuclear proteins are transported from the cytoplasm into the nucleus via nuclear envelope pore complexes (NPCs). At the molecular level, the mechanisms responsible for this transport remain obscure. However, it is known that, for many proteins, the process requires ATP and proceeds against formidable nucleocytoplasmic...

journal_title：Trends in cell biology

authors： Paine PL

更新日期：1993-10-01 00:00:00

abstract：:During the past 15 years mass spectrometry (MS)-based analyses have become established as the method of choice for direct protein identification and measurement. Owing to the remarkable improvements in the sensitivity and resolution of MS instruments, this technology has revolutionised the opportunities available for ...

journal_title：Trends in cell biology

authors： Ahmad Y,Lamond AI

更新日期：2014-04-01 00:00:00

abstract：:Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1alpha (HIF-1alp...

journal_title：Trends in cell biology

authors： Brahimi-Horn C,Berra E,Pouysségur J

更新日期：2001-11-01 00:00:00

abstract：:Endocytosis is essential for the entry of many viruses into cells. The primate lentiviruses [human immunodeficiency virus (HIV) 1 and 2, and the simian immunodeficiency viruses (SIVs)], however, use endocytosis in other aspects of their life cycles. Here, the authors describe the ways in which the endocytic pathway is...

journal_title：Trends in cell biology

authors： Marsh M,Pelchen-Matthews A,Hoxie JA

更新日期：1997-01-01 00:00:00

abstract：:Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O2) and nutrient supply. Whereas normal cells modulate anabolic and catabolic pathways in response to changes in nutrient availability, cancer cells exhibit unregulated growth even under nutrient scarci...

journal_title：Trends in cell biology

authors： Ackerman D,Simon MC

更新日期：2014-08-01 00:00:00

abstract：:The vast diversity of cellular types and behaviours is mainly the result of combinatorial interactions between a limited number of transcription factors and cellular signalling pathways whose activity is stringently controlled by developmental, cellular and extracellular cues. Studies of serum response factor (SRF) ha...

journal_title：Trends in cell biology

authors： Posern G,Treisman R

更新日期：2006-11-01 00:00:00