Cell Biology and Microbiology: A Continuous Cross-Feeding.

abstract：:Cyclin-dependent kinase 2 (CDK2) regulates diverse aspects of the mammalian cell cycle. Most cancer cells contain mutations in the pathways that control CDK2, and CDK2 activity has received much attention as a target for cancer therapy. However, a recent report demonstrating that some cancer cells can proliferate with...

journal_title：Trends in cell biology

authors： Grim JE,Clurman BE

更新日期：2003-08-01 00:00:00

abstract：:The mechanisms responsible for cytokinesis and its coordination with other events of the cell cycle are poorly understood. Genetic studies of cytokinesis in fission yeast are one useful approach to this problem. A number of conditional mutants of fission yeast that show defects in the formation of the septum of cytoki...

journal_title：Trends in cell biology

authors： Fankhauser C,Simanis V

更新日期：1994-03-01 00:00:00

abstract：:Many organisms stringently regulate the number, volume and enzymatic content of peroxisomes (and other organelles). Understanding this regulation requires knowledge of how organelles are assembled and selectively destroyed in response to metabolic cues. In the past decade, considerable progress has been achieved in th...

journal_title：Trends in cell biology

authors： Farré JC,Subramani S

更新日期：2004-09-01 00:00:00

abstract：:Lysophosphatidic acid (LPA), the smallest and structurally simplest phospholipid, is a platelet-derived serum factor that evokes a wide range of biological effects, including stimulation of fibroblast proliferation, platelet aggregation, cellular motility, tumour cell invasiveness and neurite retraction. This review s...

journal_title：Trends in cell biology

authors： Moolenaar WH

更新日期：1994-06-01 00:00:00

abstract：:The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...

journal_title：Trends in cell biology

authors： Needleman D

更新日期：2015-12-01 00:00:00

abstract：:The proteins reggie-1 and reggie-2 were originally discovered in neurons during axon regeneration. Subsequently, they were independently identified as markers of lipid rafts in flotation assays and were hence named flotillins. Since then, reggie/flotillin proteins have been found to be evolutionarily conserved and are...

journal_title：Trends in cell biology

authors： Stuermer CA

更新日期：2010-01-01 00:00:00

abstract：:During biosynthesis, MHC class II molecules travel through the endocytic pathway and interact with antigenic peptides before their stable insertion in the plasma membrane. The process of class II association with these peptides and their final deposition at the cell surface are essential steps in boosting specific ant...

journal_title：Trends in cell biology

authors： Wubbolts R,Fernandez-Bona M,Neefjes J

更新日期：1997-03-01 00:00:00

abstract：:Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo y...

journal_title：Trends in cell biology

authors： Gardner MK,Odde DJ,Bloom K

更新日期：2008-07-01 00:00:00

abstract：:The ability of cells to utilize cholesterol derived from lipoprotein is important in plasma membrane biosynthesis, steroidogenesis and the regulation of sterol synthesis. While the endocytosis of lipoprotein-derived cholesterol has been well characterized, the subsequent events that mediate its post-lysosomal intracel...

journal_title：Trends in cell biology

authors： Evans RM

更新日期：1994-05-01 00:00:00

abstract：:The proliferation of eukaryotic cells is a highly regulated process that depends on the precise duplication of chromosomal DNA in each cell cycle. Regulation of the replication licensing system, which promotes the assembly of complexes of proteins termed Mcm2-7 onto replication origins, is responsible for preventing r...

journal_title：Trends in cell biology

authors： Blow JJ,Hodgson B

更新日期：2002-02-01 00:00:00

abstract：:Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated th...

journal_title：Trends in cell biology

authors： Wei C,Yu P,Cheng L

更新日期：2020-10-01 00:00:00

abstract：:A major quest in cell biology is to understand the molecular mechanisms underlying the high plasticity of the microtubule network at different stages of the cell cycle, and during and after differentiation. Initial reports described the centrosomal localization of proteins possessing transforming acidic coiled-coil (T...

journal_title：Trends in cell biology

authors： Peset I,Vernos I

更新日期：2008-08-01 00:00:00

abstract：:During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different...

journal_title：Trends in cell biology

authors： Sonneveld S,Verhagen BMP,Tanenbaum ME

更新日期：2020-08-01 00:00:00

abstract：:Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of ...

journal_title：Trends in cell biology

authors： Norton JD,Deed RW,Craggs G,Sablitzky F

更新日期：1998-02-01 00:00:00

abstract：:All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with all other haemopoietic cells, stem cells are mobile, and it is this property of mobility that has allowed bone marrow transplantation to become a routine clinical option. Successful transplantation requires haemopoietic stem cells...

journal_title：Trends in cell biology

authors： Whetton AD,Graham GJ

更新日期：1999-06-01 00:00:00

abstract：:Understanding the basic mechanisms underlying chromatin dynamics during DNA replication in eukaryotic cells is of fundamental importance. Beyond DNA compaction, chromatin organization represents a means to regulate genome function. Thus, the inheritance and maintenance of the DNA sequence, along with its organization ...

journal_title：Trends in cell biology

authors： Corpet A,Almouzni G

更新日期：2009-01-01 00:00:00

abstract：:The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines po...

journal_title：Trends in cell biology

authors： Schubert D

更新日期：1992-03-01 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology...

journal_title：Trends in cell biology

authors： Kimata Y

更新日期：2019-07-01 00:00:00

abstract：:Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcripti...

journal_title：Trends in cell biology

authors： Yu M

更新日期：2019-04-01 00:00:00

abstract：:The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to p...

journal_title：Trends in cell biology

authors： Wang F,Higgins JM

更新日期：2013-04-01 00:00:00

abstract：:The nuclear pore complex (NPC) connects the cytoplasm and nucleus through the nuclear envelope and serves as the pipeline for moving material between the two compartments. Macromolecules that move through the NPC range in size from the very small (for example, ions and ATP) to the very large (for example, ribonucleopr...

journal_title：Trends in cell biology

authors： Talcott B,Moore MS

更新日期：1999-08-01 00:00:00

abstract：:Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of t...

journal_title：Trends in cell biology

authors： Petr MA,Tulika T,Carmona-Marin LM,Scheibye-Knudsen M

更新日期：2020-02-01 00:00:00

abstract：:The number of invited women speakers at scientific meetings is much less than their proportion in a field. This means that women have fewer venues to present their research, less opportunity to increase their professional network, and smaller chances of promotion and financial support. The paucity of women speakers al...

journal_title：Trends in cell biology

authors： Masur SK

更新日期：2015-08-01 00:00:00

abstract：:Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. This form of iron-dependent cell death is genetically, biochemically, and morp...

journal_title：Trends in cell biology

authors： Yang WS,Stockwell BR

更新日期：2016-03-01 00:00:00

abstract：:The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and severing actin filaments. ...

journal_title：Trends in cell biology

authors： Bamburg JR,McGough A,Ono S

更新日期：1999-09-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are major threats to the genomic integrity of cells. If not taken care of properly, they can cause chromosome fragmentation, loss and translocation, possibly resulting in carcinogenesis. Upon DSB formation, cell-cycle checkpoints are triggered and multiple DSB repair pathways can be act...

journal_title：Trends in cell biology

authors： Kanaar R,Hoeijmakers JH,van Gent DC

更新日期：1998-12-01 00:00:00

abstract：:A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminatin...

journal_title：Trends in cell biology

authors： Sesti F,Liu S,Cai SQ

更新日期：2010-01-01 00:00:00

abstract：:The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural ...

journal_title：Trends in cell biology

authors： Machamer CE

更新日期：2003-06-01 00:00:00

abstract：:Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2). This has major implications for s...

journal_title：Trends in cell biology

authors： Temple MD,Perrone GG,Dawes IW

更新日期：2005-06-01 00:00:00

abstract：:How do the many different components of an organelle assemble into a functional structure at an appropriate place and time? Flagellar regeneration by the biflagellate green alga Chlamydomonas is one experimental system in which genetics, biochemistry and ultrastructural analysis are being combined to investigate the a...

journal_title：Trends in cell biology

authors： Johnson KA,Rosenbaum JL

更新日期：1993-05-01 00:00:00