Golgi disassembly in apoptosis: cause or effect?

Abstract:

:The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural proteins and subsequent disassembly of the organelle could simply be the result of the apoptotic process. However, recent studies raise the intriguing possibility that cleavage of Golgi proteins during apoptosis might be required for more than disassembly of the organelle.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Machamer CE

doi

10.1016/s0962-8924(03)00101-6

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

279-81

issue

6

eissn

0962-8924

issn

1879-3088

pii

S0962892403001016

journal_volume

13

pub_type

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