Golgi disassembly in apoptosis: cause or effect?


:The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural proteins and subsequent disassembly of the organelle could simply be the result of the apoptotic process. However, recent studies raise the intriguing possibility that cleavage of Golgi proteins during apoptosis might be required for more than disassembly of the organelle.


Trends Cell Biol


Trends in cell biology


Machamer CE




Has Abstract


2003-06-01 00:00:00














  • Lipid Metabolism in Regulation of Macrophage Functions.

    abstract::Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue repair in response to tissue injury. Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we re...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Yan J,Horng T

    更新日期:2020-12-01 00:00:00

  • Actin coats and rings promote regulated exocytosis.

    abstract::It is well known that actin can associate with intracellular membranes to drive endocytosis and the rocketing motion of bacteria, virions and some organelles and to regulate synaptic vesicle plasticity. Actin also has been extensively reported to be involved at several steps of exocytosis; however, it has typically be...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Nightingale TD,Cutler DF,Cramer LP

    更新日期:2012-06-01 00:00:00

  • Synergistic Mechano-Chemical Sensing by Vascular Cilia.

    abstract::Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling. ...

    journal_title:Trends in cell biology

    pub_type: 评论,杂志文章


    authors: Follain G,Goetz JG

    更新日期:2018-07-01 00:00:00

  • Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing.

    abstract::There is a pronounced tendency among cell biologists to focus on qualitative aspects of cell physiology. The remarkable accomplishments of evolution in creating cells can only be fully appreciated, however, by combining this qualitative analysis with a quantitative assessment of cellular constituents and processes. He...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Yewdell JW

    更新日期:2001-07-01 00:00:00

  • Interface between Physics and Biology: Training a New Generation of Creative Bilingual Scientists.

    abstract::Whereas physics seeks for universal laws underlying natural phenomena, biology accounts for complexity and specificity of molecular details. Contemporary biological physics requires people capable of working at this interface. New programs prepare scientists who transform respective disciplinary views into innovative ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Riveline D,Kruse K

    更新日期:2017-08-01 00:00:00

  • The Different Routes to Metastasis via Hypoxia-Regulated Programs.

    abstract::Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Nobre AR,Entenberg D,Wang Y,Condeelis J,Aguirre-Ghiso JA

    更新日期:2018-11-01 00:00:00

  • Turning up the Green Light.

    abstract::Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Cassereau J,Courdavault V,Nägerl UV

    更新日期:2020-12-29 00:00:00

  • Probing phosphoinositide functions in signaling and membrane trafficking.

    abstract::The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. PIs are among the most versatile signaling molecules known, with key roles in receptor-mediated signal transduction, actin remodeling and membrane trafficking. Recent s...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Downes CP,Gray A,Lucocq JM

    更新日期:2005-05-01 00:00:00

  • JAKs and STATs branch out.

    abstract::The JAK-STAT signal-transduction pathway is utilized by a wide range of cytokines to regulate gene expression. Cytokines activate members of the JAK family o f protein tyrosine kinases, which in turn activate, by tyrosine phosphorylation, one or more STAT transcription factor family members. Activated STATs form dimer...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Briscoe J,Kohlhuber F,Müller M

    更新日期:1996-09-01 00:00:00

  • Sorting nuclear membrane proteins at mitosis.

    abstract::The nuclear envelope (NE) breaks down reversibly and reassembles at mitosis. Two models of mitotic nuclear membrane disassembly and reformation have emerged from studies of NE dynamics in somatic cells and egg extracts. One model suggests that nuclear membranes fragment reversibly by vesiculation, producing NE-derived...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Collas P,Courvalin JC

    更新日期:2000-01-01 00:00:00

  • Germline cysts: a conserved phase of germ cell development?

    abstract::Germ cells in many vertebrate and invertebrate species initiate gametogenesis by forming groups of interconnected cells known as germline cysts. Recent studies using Xenopus, mouse and Drosophila are beginning to uncover the cellular and molecular mechanisms that control germline cyst formation and, in conjunction wit...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Pepling ME,de Cuevas M,Spradling AC

    更新日期:1999-07-01 00:00:00

  • p130Cas: a versatile scaffold in signaling networks.

    abstract::The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular signaling events. Although these proteins do not have enzymatic or transcriptional activity, they spatially and temporally control signaling events through their ability to undergo changes in phosphorylation and to associate w...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Defilippi P,Di Stefano P,Cabodi S

    更新日期:2006-05-01 00:00:00

  • 'Disc-o-Fever': Getting Down with Giardia's Groovy Microtubule Organelle.

    abstract::Protists have evolved a myriad of highly specialized cytoskeletal organelles that expand known functional capacities of microtubule (MT) polymers. One such innovation - the ventral disc - is a cup-shaped MT organelle that the parasite Giardia uses to attach to the small intestine of its host. The molecular mechanisms ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Nosala C,Hagen KD,Dawson SC

    更新日期:2018-02-01 00:00:00

  • Lysosomes nor Mice Move Forward without Borcs7.

    abstract::Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...

    journal_title:Trends in cell biology

    pub_type: 评论,杂志文章


    authors: Joshi U,Houwman JA,van der Sluijs P

    更新日期:2018-10-01 00:00:00

  • Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information.

    abstract::Understanding the basic mechanisms underlying chromatin dynamics during DNA replication in eukaryotic cells is of fundamental importance. Beyond DNA compaction, chromatin organization represents a means to regulate genome function. Thus, the inheritance and maintenance of the DNA sequence, along with its organization ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Corpet A,Almouzni G

    更新日期:2009-01-01 00:00:00

  • Moving forward: polarised trafficking in cell migration.

    abstract::Polarised vesicle trafficking has been suggested to regulate cell migration. Understanding how this takes place has been complicated by the use of disparate assays and cellular models. Although polarised trafficking does occur in cell motility it is not clear which pathways are involved. We propose a model for migrati...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Fletcher SJ,Rappoport JZ

    更新日期:2010-02-01 00:00:00

  • Tales of Detailed Poly(A) Tails.

    abstract::Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stabil...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Nicholson AL,Pasquinelli AE

    更新日期:2019-03-01 00:00:00

  • Virtual gating and nuclear transport: the hole picture.

    abstract::The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole mediators of exchange between the nucleus and the cytoplasm. Small molecules pass through the NPCs unchallenged; however, large macromolecules a...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Rout MP,Aitchison JD,Magnasco MO,Chait BT

    更新日期:2003-12-01 00:00:00

  • Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player.

    abstract::The regulation of endothelial cell contacts is of central importance for the barrier function of the blood vessel wall and for the control of leukocyte extravasation. In addition, the plasticity of endothelial cell contacts is regulated during angiogenesis by growth factors, such as vascular endothelial growth factor ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Vestweber D,Winderlich M,Cagna G,Nottebaum AF

    更新日期:2009-01-01 00:00:00

  • CGH-1 and the control of maternal mRNAs.

    abstract::Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Rajyaguru P,Parker R

    更新日期:2009-01-01 00:00:00

  • Intracellular proteolysis.

    abstract::Our present understanding of intracellular protein degradation developed from an attempt to understand the metabolic stability of proteins in cells. With the unravelling of its complex biochemical machinery has come a realization that protein degradation plays an important role in the most crucial events in the cell c...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Kirschner M

    更新日期:1999-12-01 00:00:00

  • Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease.

    abstract::Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocyto...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Marks DL,Pagano RE

    更新日期:2002-12-01 00:00:00

  • Endogenous Fluorescence Tagging by CRISPR.

    abstract::Fluorescent proteins have revolutionized biomedical research as they are easy to use for protein tagging, cope without fixation or permeabilization, and thus, enable live cell imaging in various models. Current methods allow easy and quick integration of fluorescent markers to endogenous genes of interest. In this rev...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Bukhari H,Müller T

    更新日期:2019-11-01 00:00:00

  • On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype.

    abstract::If eukaryotes arose through a merger between archaea and bacteria, what did the first true eukaryotic cell look like? A major step toward an answer came with the discovery of Lokiarchaeum, an archaeon whose genome encodes small GTPases related to those used by eukaryotes to regulate membrane traffic. Although 'Loki' c...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Dey G,Thattai M,Baum B

    更新日期:2016-07-01 00:00:00

  • Hematopoietic Reprogramming Entangles with Hematopoiesis.

    abstract::Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Wei C,Yu P,Cheng L

    更新日期:2020-10-01 00:00:00

  • FH proteins as cytoskeletal organizers.

    abstract::Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discu...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Wasserman S

    更新日期:1998-03-01 00:00:00

  • Breaching the basement membrane: who, when and how?

    abstract::The basement membrane (BM), a specialized network of extracellular matrix macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells. During development, immune surveillance and disease states ranging from cancer to fibrosis, host cells penetrate the BM by engaging tissue-invasive programs, the ide...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Rowe RG,Weiss SJ

    更新日期:2008-11-01 00:00:00

  • Roles for endocytosis in lentiviral replication.

    abstract::Endocytosis is essential for the entry of many viruses into cells. The primate lentiviruses [human immunodeficiency virus (HIV) 1 and 2, and the simian immunodeficiency viruses (SIVs)], however, use endocytosis in other aspects of their life cycles. Here, the authors describe the ways in which the endocytic pathway is...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Marsh M,Pelchen-Matthews A,Hoxie JA

    更新日期:1997-01-01 00:00:00

  • Joining the cell survival squad: an emerging role for protein kinase CK2.

    abstract::Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ahmed K,Gerber DA,Cochet C

    更新日期:2002-05-01 00:00:00

  • Hierarchy and Plasticity in the Intestinal Stem Cell Compartment.

    abstract::Somatic stem cells maintain tissue homeostasis by organizing themselves in such a way that they can maintain proliferative output while simultaneously protecting themselves from DNA damage that may lead to oncogenic transformation. There is considerable debate about how such stem cell compartments are organized. Burge...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Yousefi M,Li L,Lengner CJ

    更新日期:2017-10-01 00:00:00