Abstract:
:It was once believed that common mechanisms underpin the transfer of proteins across the membrane systems of organelles such as mitochondria, chloroplasts and peroxisomes. Now that many of the core components of the translocases have been indentified, results discussed at a recent conference [Max-Delbrück-Centrum Symposium "Protein Transport and Stability"; Berlin, Germany; 21-26 March 2001. Organized by Thomas Sommer and Enno Hartmann.] stress just how diverse the mechanisms of transport into these organelles really are.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Kunau WH,Agne B,Girzalsky Wdoi
10.1016/s0962-8924(01)02083-9subject
Has Abstractpub_date
2001-09-01 00:00:00pages
358-61issue
9eissn
0962-8924issn
1879-3088pii
S0962892401020839journal_volume
11pub_type
杂志文章abstract::Cellular organization of the cytoskeleton, assembly of intracellular signaling complexes and movement of membrane receptors into supramolecular activation complexes (SMACs) are crucial prerequisites for lymphocyte activation and function. Full T-cell activation requires costimulatory signals in addition to antigen-med...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(01)01981-x
更新日期:2001-05-01 00:00:00
abstract::The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2015.08.011
更新日期:2015-12-01 00:00:00
abstract::The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(00)01727-x
更新日期:2000-04-01 00:00:00
abstract::A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminatin...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2009.09.008
更新日期:2010-01-01 00:00:00
abstract::The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/S0962-8924(97)01079-9
更新日期:1997-07-01 00:00:00
abstract::Scientific research relies on a range of technologies, many of which are developing at a fast pace. Technical experts able to advise researchers on experimental design and validate the performance1 of shared instruments are increasingly recognized as critical members of the research community. Here I describe a novel ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2020.06.001
更新日期:2020-09-01 00:00:00
abstract::Export signal sequences target newly synthesized proteins to the endoplasmic reticulum of eukaryotic cells and the plasma membrane of bacteria. All signal sequences contain a hydrophobic core region, but, despite this, they show great variation in both overall length and amino acid sequence. Recently, it has become cl...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(98)01360-9
更新日期:1998-10-01 00:00:00
abstract::Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to th...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/j.tcb.2012.01.004
更新日期:2012-04-01 00:00:00
abstract::Research on fibroblast biology in three-dimensional collagen matrices offers new opportunities to understand the reciprocal and adaptive interactions that occur between cells and surrounding matrix in a tissue-like environment. Such interactions are integral to the regulation of connective tissue morphogenesis and dyn...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(03)00057-6
更新日期:2003-05-01 00:00:00
abstract::The nucleus is a spatially organized compartment. The most obvious way in which this is achieved is at the level of chromosomes. The positioning of chromosomes with respect to nuclear landmarks and with respect to each other is both non-random and cell-type specific. This suggests that cells possess molecular mechanis...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.08.001
更新日期:2011-12-01 00:00:00
abstract::Meiosis is a specialized type of cell division leading to the production of gametes. During meiotic prophase I, homologous chromosomes interact with each other and form bivalents (pairs of homologous chromosomes). Three major meiotic processes--chromosome pairing, synapsis and recombination--are involved in the format...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2005.10.005
更新日期:2005-12-01 00:00:00
abstract::The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole mediators of exchange between the nucleus and the cytoplasm. Small molecules pass through the NPCs unchallenged; however, large macromolecules a...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2003.10.007
更新日期:2003-12-01 00:00:00
abstract::Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome mis-segregation into a micronucleus or chromatin br...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2017.08.005
更新日期:2017-12-01 00:00:00
abstract::The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines po...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/0962-8924(92)90057-t
更新日期:1992-03-01 00:00:00
abstract::Why are women so under-represented at the top echelons of science? Why do so many drop out just as their careers should be blossoming? Are women in science being actively discriminated against by their peers, and, if, so what can be done about this? These were just a few of the puzzles reflected upon at a recent Europ...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/s0962-8924(01)02182-1
更新日期:2001-11-01 00:00:00
abstract::Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocyto...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(02)02399-1
更新日期:2002-12-01 00:00:00
abstract::Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the id...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(02)02279-1
更新日期:2002-05-01 00:00:00
abstract::Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.04.005
更新日期:2011-09-01 00:00:00
abstract::Diabetes is a metabolic disease affecting nearly 300 million individuals worldwide. Both types of diabetes (1 and 2) are characterized by loss of functional pancreatic β-cell mass causing different degrees of insulin deficiency. The Bcl-2 family has a double-edged effect in diabetes. These proteins are crucial control...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.03.001
更新日期:2011-07-01 00:00:00
abstract::The organization of cells into interconnected structures such as animal tissues requires a sophisticated system directing receptors and adhesion proteins to the cell surface. The Rab11 small G proteins (Rab11a, b, and Rab25) of the Ras superfamily are master regulators of the surface expression of receptors and adhesi...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2014.02.004
更新日期:2014-07-01 00:00:00
abstract::Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family member...
journal_title:Trends in cell biology
pub_type: 杂志文章
doi:10.1016/S0962-8924(97)01105-7
更新日期:1997-09-01 00:00:00
abstract::The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transact...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2012.11.007
更新日期:2013-04-01 00:00:00
abstract::A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is ...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(98)01295-1
更新日期:1998-07-01 00:00:00
abstract::Until recently, the cell biology of mammalian muscle repair following damage appeared to be completely different from the formation of new muscles in regenerated appendages of Amphibia. Mammalian muscle repair occurs through the mobilization of muscle satellite cells, whereas the new muscle in amphibian appendage rege...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2006.04.007
更新日期:2006-06-01 00:00:00
abstract::DNA double-strand breaks (DSBs) are major threats to the genomic integrity of cells. If not taken care of properly, they can cause chromosome fragmentation, loss and translocation, possibly resulting in carcinogenesis. Upon DSB formation, cell-cycle checkpoints are triggered and multiple DSB repair pathways can be act...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0962-8924(98)01383-x
更新日期:1998-12-01 00:00:00
abstract::Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates. Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different. I...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2012.10.011
更新日期:2013-03-01 00:00:00
abstract::The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicat...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2003.12.008
更新日期:2004-02-01 00:00:00
abstract::Stem cell niches are specialized microenvironments where pluripotent cells are maintained to provide undifferentiated cells for the formation of new tissues and organs. The balance between stem cell maintenance within the niche and differentiation of cells that exit it is regulated by local cell-cell communication, to...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2007.06.002
更新日期:2007-08-01 00:00:00
abstract::Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...
journal_title:Trends in cell biology
pub_type: 评论,杂志文章
doi:10.1016/j.tcb.2018.08.002
更新日期:2018-10-01 00:00:00
abstract::Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has ofte...
journal_title:Trends in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.tcb.2011.06.001
更新日期:2011-09-01 00:00:00