Abstract:
:Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous protein-conducting pathway by which thousands of newly synthesized polypeptides make their way through the lipid bilayer. The channel is not a simple passive pore, however; it displays remarkable complexity by interacting with numerous soluble partners, including SecA, Syd, FtsY and the ribosome in bacteria. For several decades, scientists have been fascinated by the sophistication and versatility of this transport channel. In this review, we cover the current state of the field including some of the newest and most exciting findings on channel structure and mechanism of action.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Dalal K,Duong Fdoi
10.1016/j.tcb.2011.04.005subject
Has Abstractpub_date
2011-09-01 00:00:00pages
506-14issue
9eissn
0962-8924issn
1879-3088pii
S0962-8924(11)00074-2journal_volume
21pub_type
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