Abstract：
:Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, and additional players including junctional adhesion molecules (JAMs), membrane lipids, phase separation of the zonula occludens (ZO) family of scaffolding proteins, and mechanical force have been shown to play important roles in TJ structure and function. In this review, we discuss how these new findings have the potential to transform our understanding of TJ structure and function, and how the intricate network of TJ proteins and membrane lipids dynamically interact to drive TJ assembly.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Otani T,Furuse Mdoi
10.1016/j.tcb.2020.08.004subject
Has Abstractpub_date
2020-10-01 00:00:00pages
805-817issue
10eissn
0962-8924issn
1879-3088pii
S0962-8924(20)30151-3journal_volume
30pub_type
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