Abstract：
:Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Smad signaling that directs changes in gene expression are often seen as established. Even though TGF-β-induced Smad signaling may be seen as a linear signaling pathway with predictable outcomes, this pathway provides cells with a versatile means to induce different cellular responses. Fundamental questions remain as to how, at the molecular level, TGF-β and TGF-β family proteins activate the receptor complexes and induce a context-dependent diversity of cell responses. Among the areas of progress, we summarize new insights into how cells control TGF-β responsiveness by controlling the TGF-β receptors, and into the key roles and versatility of Smads in directing cell differentiation and cell fate selection.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Budi EH,Duan D,Derynck Rdoi
10.1016/j.tcb.2017.04.005subject
Has Abstractpub_date
2017-09-01 00:00:00pages
658-672issue
9eissn
0962-8924issn
1879-3088pii
S0962-8924(17)30063-6journal_volume
27pub_type
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