Abstract：
:Lysophosphatidic acid (LPA), the smallest and structurally simplest phospholipid, is a platelet-derived serum factor that evokes a wide range of biological effects, including stimulation of fibroblast proliferation, platelet aggregation, cellular motility, tumour cell invasiveness and neurite retraction. This review summarizes recent insights into the mode of action of LPA. LPA appears to activate its own G-protein-coupled receptor(s) to initiate both classic and novel signal cascades. Of particular interest is LPA's ability to activate the Ras pathway and to stimulate protein tyrosine phosphorylation in concert with remodelling of the actin cytoskeleton.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Moolenaar WHdoi
10.1016/0962-8924(94)90144-9subject
Has Abstractpub_date
1994-06-01 00:00:00pages
213-9issue
6eissn
0962-8924issn
1879-3088pii
0962892494901449journal_volume
4pub_type
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更新日期：2018-11-01 00:00:00
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更新日期：2014-05-01 00:00:00
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journal_title：Trends in cell biology
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更新日期：2013-01-01 00:00:00
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journal_title：Trends in cell biology
pub_type： 杂志文章
doi：10.1016/s0962-8924(99)01509-3
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journal_title：Trends in cell biology
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journal_title：Trends in cell biology
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abstract：:RNA-binding proteins are involved in various aspects of RNA metabolism such as processing, translational control, stabilization, localization and transport. Many of these proteins bind several RNA targets and have multiple functions. In this review we focus on RNA-binding proteins that are implicated in RNA transport ...
journal_title：Trends in cell biology
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abstract：:The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM he...
journal_title：Trends in cell biology
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