LPA: a novel lipid mediator with diverse biological actions.

Abstract:

:Lysophosphatidic acid (LPA), the smallest and structurally simplest phospholipid, is a platelet-derived serum factor that evokes a wide range of biological effects, including stimulation of fibroblast proliferation, platelet aggregation, cellular motility, tumour cell invasiveness and neurite retraction. This review summarizes recent insights into the mode of action of LPA. LPA appears to activate its own G-protein-coupled receptor(s) to initiate both classic and novel signal cascades. Of particular interest is LPA's ability to activate the Ras pathway and to stimulate protein tyrosine phosphorylation in concert with remodelling of the actin cytoskeleton.

journal_name

Trends Cell Biol

journal_title

Trends in cell biology

authors

Moolenaar WH

doi

10.1016/0962-8924(94)90144-9

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

213-9

issue

6

eissn

0962-8924

issn

1879-3088

pii

0962892494901449

journal_volume

4

pub_type

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