LPA: a novel lipid mediator with diverse biological actions.


:Lysophosphatidic acid (LPA), the smallest and structurally simplest phospholipid, is a platelet-derived serum factor that evokes a wide range of biological effects, including stimulation of fibroblast proliferation, platelet aggregation, cellular motility, tumour cell invasiveness and neurite retraction. This review summarizes recent insights into the mode of action of LPA. LPA appears to activate its own G-protein-coupled receptor(s) to initiate both classic and novel signal cascades. Of particular interest is LPA's ability to activate the Ras pathway and to stimulate protein tyrosine phosphorylation in concert with remodelling of the actin cytoskeleton.


Trends Cell Biol


Trends in cell biology


Moolenaar WH




Has Abstract


1994-06-01 00:00:00














  • Tug of War in the Xenophagy World.

    abstract::Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al., Cell, 2019) used the discovery of an inhibitor of xenophagy, SopF,...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Pao KC,Rape M

    更新日期:2019-10-01 00:00:00

  • Regulation of endocytic traffic by rho family GTPases.

    abstract::Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signallin...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ellis S,Mellor H

    更新日期:2000-03-01 00:00:00

  • Sorting nuclear membrane proteins at mitosis.

    abstract::The nuclear envelope (NE) breaks down reversibly and reassembles at mitosis. Two models of mitotic nuclear membrane disassembly and reformation have emerged from studies of NE dynamics in somatic cells and egg extracts. One model suggests that nuclear membranes fragment reversibly by vesiculation, producing NE-derived...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Collas P,Courvalin JC

    更新日期:2000-01-01 00:00:00

  • Zebrafish Infection: From Pathogenesis to Cell Biology.

    abstract::The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counte...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Torraca V,Mostowy S

    更新日期:2018-02-01 00:00:00

  • Surfing on a retrograde wave: how does Shiga toxin reach the endoplasmic reticulum?

    abstract::Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway a...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Johannes L,Goud B

    更新日期:1998-04-01 00:00:00

  • Proteostasis impairment in protein-misfolding and -aggregation diseases.

    abstract::Cells possess an extensive network of components to safeguard proteome integrity and maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines in performance, as may be the case during aging, newly synthesized proteins are no longer able to fold efficiently and metastable proteins lose ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Hipp MS,Park SH,Hartl FU

    更新日期:2014-09-01 00:00:00

  • ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum.

    abstract::The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and ion storage. To maintain its function, it is turned over constitutively, and even more actively under certain stress conditions. Quality con...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Chino H,Mizushima N

    更新日期:2020-05-01 00:00:00

  • Breaking away: matrix remodeling from the leading edge.

    abstract::Substantial progress has been made in recent years toward understanding the molecular mechanisms by which tumor cells, and the supporting stroma, degrade confining matrix during migration. Significant attention has been focused on understanding the biology of several dynamic and distinct, but remarkably related, cell ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: McNiven MA

    更新日期:2013-01-01 00:00:00

  • Membrane Architecture in the Spotlight of Correlative Microscopy.

    abstract::Cellular membranes differ in their molecular organisation, shape, and dynamics. Knowing how these properties of membrane architecture relate to the presence and function of specific membrane components is fundamental for understanding membrane-associated cellular processes. Correlative light and electron microscopy (C...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ganeva I,Kukulski W

    更新日期:2020-07-01 00:00:00

  • Quantitative cell biology with the Virtual Cell.

    abstract::Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational models, comprising quantitative data on the interacting molecular participants in these events, provide a means for applying the scientifi...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Slepchenko BM,Schaff JC,Macara I,Loew LM

    更新日期:2003-11-01 00:00:00

  • Histone modifications and mitosis: countermarks, landmarks, and bookmarks.

    abstract::The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to p...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Wang F,Higgins JM

    更新日期:2013-04-01 00:00:00

  • Collaborative interactions between growth factors and the extracellular matrix.

    abstract::The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines po...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


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    更新日期:1992-03-01 00:00:00

  • Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.

    abstract::While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Barlow CA,Laishram RS,Anderson RA

    更新日期:2010-01-01 00:00:00

  • Functions of Microtubule Disassembly during Neurite Pruning.

    abstract::Large-scale neurite pruning, the developmentally regulated degeneration of axons or dendrites, is an important specificity mechanism during neuronal circuit formation. Pruning is usually restricted to single neurite branches and can occur by local degeneration or retraction. How this spatial regulation is achieved, an...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Rumpf S,Wolterhoff N,Herzmann S

    更新日期:2019-04-01 00:00:00

  • Putting a new twist on actin: ADF/cofilins modulate actin dynamics.

    abstract::The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the rate constants of polymerization and depolymerization at filament ends, changing the twist of the filament and severing actin filaments. ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Bamburg JR,McGough A,Ono S

    更新日期:1999-09-01 00:00:00

  • Synergistic Mechano-Chemical Sensing by Vascular Cilia.

    abstract::Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling. ...

    journal_title:Trends in cell biology

    pub_type: 评论,杂志文章


    authors: Follain G,Goetz JG

    更新日期:2018-07-01 00:00:00

  • Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

    abstract::DNA double-strand breaks (DSBs) are the most toxic DNA lesions given their oncogenic potential. Nevertheless, programmed DSBs (prDSBs) contribute to several biological processes. Formation of prDSBs is the 'price to pay' to achieve these essential biological functions. Generated by domesticated PiggyBac transposases, ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Bétermier M,Borde V,de Villartay JP

    更新日期:2020-02-01 00:00:00

  • Role of MINOS in mitochondrial membrane architecture and biogenesis.

    abstract::Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: van der Laan M,Bohnert M,Wiedemann N,Pfanner N

    更新日期:2012-04-01 00:00:00

  • The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.

    abstract::In response to stress, p53 initiates the transcriptional regulation of selected target genes and various cellular responses, including cell cycle arrest, apoptosis and senescence. Recent studies revealed two additional functions of p53 in the regulation of IGF-1/AKT/mTOR pathways and energy metabolism, contributing to...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Feng Z,Levine AJ

    更新日期:2010-07-01 00:00:00

  • Molecular mechanisms of DNA double strand break repair.

    abstract::DNA double-strand breaks (DSBs) are major threats to the genomic integrity of cells. If not taken care of properly, they can cause chromosome fragmentation, loss and translocation, possibly resulting in carcinogenesis. Upon DSB formation, cell-cycle checkpoints are triggered and multiple DSB repair pathways can be act...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Kanaar R,Hoeijmakers JH,van Gent DC

    更新日期:1998-12-01 00:00:00

  • Endoreplication: The Good, the Bad, and the Ugly.

    abstract::To battle adverse internal and external conditions and maintain homeostasis, diploid organisms employ various cellular processes, such as proliferation and apoptosis. In some tissues, an alternative mechanism, endoreplication, is employed toward similar goals. Endoreplication is an evolutionarily conserved cell cycle ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Shu Z,Row S,Deng WM

    更新日期:2018-06-01 00:00:00

  • Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases.

    abstract::An important aspect of cell behaviour is that DNA replication happens only once per cell cycle. Replicated DNA is unable to re-replicate until cell division has occurred. Unreplicated DNA is in a replication-competent or 'licensed' state. The ability to replicate is lost in S phase and regained following passage throu...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Romanowski P,Madine MA

    更新日期:1996-05-01 00:00:00

  • The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation.

    abstract::Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Tornatore L,Thotakura AK,Bennett J,Moretti M,Franzoso G

    更新日期:2012-11-01 00:00:00

  • The ins and outs of Wingless signaling.

    abstract::Signaling through the highly conserved Wingless/Wnt pathway plays a crucial role in a diverse array of developmental processes, many of which depend upon the precise regulation of Wingless/Wnt signaling levels. Recent evidence has indicated that the intracellular trafficking of Wingless/Wnt signaling components can re...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Seto ES,Bellen HJ

    更新日期:2004-01-01 00:00:00

  • Inflammatory cells during wound repair: the good, the bad and the ugly.

    abstract::Damage to any tissue triggers a cascade of events that leads to rapid repair of the wound - if the tissue is skin, then repair involves re-epithelialization, formation of granulation tissue and contraction of underlying wound connective tissues. This concerted effort by the wounded cell layers is accompanied by, and m...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Martin P,Leibovich SJ

    更新日期:2005-11-01 00:00:00

  • New regulatory mechanisms of TGF-beta receptor function.

    abstract::Transforming growth factor-beta (TGF-beta) regulates cell proliferation, differentiation and apoptosis, and TGF-beta-related proteins have key roles in development, tissue homeostasis and disease. Upon binding to their cell surface receptors, TGF-beta family proteins signal through Smads to induce changes in gene expr...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Kang JS,Liu C,Derynck R

    更新日期:2009-08-01 00:00:00

  • Mitochondrial ROS--radical detoxification, mediated by protein kinase D.

    abstract::The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threoni...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Storz P

    更新日期:2007-01-01 00:00:00

  • The Different Routes to Metastasis via Hypoxia-Regulated Programs.

    abstract::Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Nobre AR,Entenberg D,Wang Y,Condeelis J,Aguirre-Ghiso JA

    更新日期:2018-11-01 00:00:00

  • Proteins on the move: dynamic protein localization in prokaryotes.

    abstract::Despite their small size and lack of obvious intracellular structures, bacteria have a complex and dynamic intracellular organization. Recent work has shown that many proteins, and even regions of the chromosome, are localized to specific subcellular regions that can change over time, sometimes extraordinarily fast. P...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Jensen RB,Shapiro L

    更新日期:2000-11-01 00:00:00

  • Epithelial organization, cell polarity and tumorigenesis.

    abstract::Epithelial cells comprise the foundation for the majority of organs in the mammalian body, and are the source of approximately 90% of all human cancers. Characteristically, epithelial cells form intercellular adhesions, exhibit apical/basal polarity, and orient their mitotic spindles in the plane of the epithelial she...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: McCaffrey LM,Macara IG

    更新日期:2011-12-01 00:00:00