Abstract：
:Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is structurally similar to mRNA-helicases and MSS4. TPT1/TCTP has recently been identified as a prognostic factor in breast cancer and a critical regulator of the tumor suppressor p53 and of the cancer stem cell (SC) compartment. Emerging evidence indicates that TPT1/TCTP is key to phenotypic reprogramming, as shown in the process of tumor reversion and possibly in pluripotency. We provide here an overview of these diverse functions of TPT1/TCTP.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Amson R,Pece S,Marine JC,Di Fiore PP,Telerman Adoi
10.1016/j.tcb.2012.10.002subject
Has Abstractpub_date
2013-01-01 00:00:00pages
37-46issue
1eissn
0962-8924issn
1879-3088pii
S0962-8924(12)00180-8journal_volume
23pub_type
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