Nuclear Architecture: Past and Future Tense.


:The architecture of the interphase nucleus remains a treasure trove for explorers of the 3D folding of macromolecules, like DNA, and of their related functions. Only recently has there been insight into how transient interactions of the genome and its associated proteins, in space and time, facilitate transcription, replication, and repair.


Trends Cell Biol


Trends in cell biology


Gasser SM




Has Abstract


2016-07-01 00:00:00














  • The nuclear connection in RNA transport and localization.

    abstract::RNA-binding proteins are involved in various aspects of RNA metabolism such as processing, translational control, stabilization, localization and transport. Many of these proteins bind several RNA targets and have multiple functions. In this review we focus on RNA-binding proteins that are implicated in RNA transport ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Farina KL,Singer RH

    更新日期:2002-10-01 00:00:00

  • Getting across the nuclear pore complex.

    abstract::The nuclear pore complex (NPC) connects the cytoplasm and nucleus through the nuclear envelope and serves as the pipeline for moving material between the two compartments. Macromolecules that move through the NPC range in size from the very small (for example, ions and ATP) to the very large (for example, ribonucleopr...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Talcott B,Moore MS

    更新日期:1999-08-01 00:00:00

  • Subcellular Chemical Imaging: New Avenues in Cell Biology.

    abstract::To better understand the physiology and acclimation capability of the cell, one of the great challenges of the future is to access the interior of a cell and unveil its chemical landscape (composition and distribution of elements and molecules). Chemical imaging has greatly improved in sensitivity and spatial resoluti...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Decelle J,Veronesi G,Gallet B,Stryhanyuk H,Benettoni P,Schmidt M,Tucoulou R,Passarelli M,Bohic S,Clode P,Musat N

    更新日期:2020-03-01 00:00:00

  • Communicating by touch--neurons are not alone.

    abstract::Long-distance cell-cell communication is essential for organ development and function. Whereas neurons communicate at long distances by transferring signals at sites of direct contact (i.e., at synapses), it has been presumed that the only way other cell types signal is by dispersing signals through extracellular flui...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Kornberg TB,Roy S

    更新日期:2014-06-01 00:00:00

  • Time To Split Up: Dynamics of Chromosome Separation.

    abstract::The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regula...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Kamenz J,Hauf S

    更新日期:2017-01-01 00:00:00

  • Histone modifications and mitosis: countermarks, landmarks, and bookmarks.

    abstract::The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to p...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Wang F,Higgins JM

    更新日期:2013-04-01 00:00:00

  • Emerging Roles for the Lysosome in Lipid Metabolism.

    abstract::Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and nonvesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the cross...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Thelen AM,Zoncu R

    更新日期:2017-11-01 00:00:00

  • TPT1/ TCTP-regulated pathways in phenotypic reprogramming.

    abstract::Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Amson R,Pece S,Marine JC,Di Fiore PP,Telerman A

    更新日期:2013-01-01 00:00:00

  • The spindle checkpoint: two transitions, two pathways.

    abstract::The spindle checkpoint is an evolutionarily conserved mitotic regulatory mechanism that ensures that anaphase is not attempted until chromosomes are properly aligned on the spindle. Two different cell-cycle transitions must be inhibited by the spindle checkpoint to arrest cells at metaphase and prevent mitotic exit. T...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Gardner RD,Burke DJ

    更新日期:2000-04-01 00:00:00

  • The search for physiological substrates of MAP and SAP kinases in mammalian cells.

    abstract::Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family member...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Cohen P

    更新日期:1997-09-01 00:00:00

  • Polarizing without a c(l)ue.

    abstract::Most cells polarize in response to an asymmetric signal but some can spontaneously establish a discrete axis of polarity in the absence of a directional cue. Many mathematical models predict that locally acting positive feedback loops and globally acting negative regulators are required for pattern formation. Here, we...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Sohrmann M,Peter M

    更新日期:2003-10-01 00:00:00

  • Information Theory: New Look at Oncogenic Signaling Pathways.

    abstract::Sustained pro-proliferative signaling is one of the hallmarks of cancer. Although it is generally understood that the oncogenic signaling pathways are overactivated, or at least abnormally activated, in cancer cells, important mechanistic details of such abnormal activation remain unresolved. Among these details are s...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Zielińska KA,Katanaev VL

    更新日期:2019-11-01 00:00:00

  • Special-interest subgroups at the ASCB: Tau protein in neurodegenerative disease.

    abstract::The annual meeting of the American Society for Cell Biology (ASCB) is a large and diverse gathering. At last year's meeting**The American Society for Cell Biology 38th Annual Meeting, San Francisco, USA; 12-16 December, 1998. Program chair: Jennifer Lippincott-Schwartz., there were over 8000 attendees, and the topics ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Lee G

    更新日期:1999-03-01 00:00:00

  • Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases.

    abstract::An important aspect of cell behaviour is that DNA replication happens only once per cell cycle. Replicated DNA is unable to re-replicate until cell division has occurred. Unreplicated DNA is in a replication-competent or 'licensed' state. The ability to replicate is lost in S phase and regained following passage throu...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Romanowski P,Madine MA

    更新日期:1996-05-01 00:00:00

  • The Material Basis of Life.

    abstract::The manner by which the organization and behaviors of cells arise from the activities of their constituent molecules remains poorly understood. Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Needleman D

    更新日期:2015-12-01 00:00:00

  • Reverse leukocyte migration can be attractive or repulsive.

    abstract::The directional migration of cells within multicellular organisms is governed by gradients of both chemical attractants and repellents in diverse processes, including leukocyte trafficking and neuronal pathfinding in vivo. These complex extracellular environments direct the orchestrated bidirectional trafficking of le...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Huttenlocher A,Poznansky MC

    更新日期:2008-06-01 00:00:00

  • Compartmentalization of the nucleus.

    abstract::The nucleus is a spatially organized compartment. The most obvious way in which this is achieved is at the level of chromosomes. The positioning of chromosomes with respect to nuclear landmarks and with respect to each other is both non-random and cell-type specific. This suggests that cells possess molecular mechanis...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Meldi L,Brickner JH

    更新日期:2011-12-01 00:00:00

  • From Planar Cell Polarity to Ciliogenesis and Back: The Curious Tale of the PPE and CPLANE proteins.

    abstract::Why some genes are more popular than others remains an open question, but one example of this phenomenon involves the genes controlling planar cell polarity (PCP), the polarization of cells within a plane of a tissue. Indeed, the so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been extensive...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Adler PN,Wallingford JB

    更新日期:2017-05-01 00:00:00

  • Are renal ciliopathies (replication) stressed out?

    abstract::Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunct...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Slaats GG,Giles RH

    更新日期:2015-06-01 00:00:00

  • Protein sorting and secretion granule formation in regulated secretory cells.

    abstract::Formation of secretion granules in regulated secretory cells involves packaging a subject of proteins undergoing intracellular transport into specific vesicular carriers that function in stimulus-dependent exocytosis. Recent findings suggest that immature granules are a site of passive sorting, involving condensation ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Arvan P,Castle D

    更新日期:1992-11-01 00:00:00

  • Role of MINOS in mitochondrial membrane architecture and biogenesis.

    abstract::Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to th...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: van der Laan M,Bohnert M,Wiedemann N,Pfanner N

    更新日期:2012-04-01 00:00:00

  • Signal transduction during mating and meiosis in S. pombe.

    abstract::When starved, the fission yeast Schizosaccharomyces pombe responds by producing mating factors or pheromones that signal to cells of the opposite sex to initiate mating. Like its distant relative Saccharomyces cerevisiae, cells of the two mating types of S. pombe each produce a distinct pheromone that binds to recepto...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Nielsen O

    更新日期:1993-02-01 00:00:00

  • Germline cysts: a conserved phase of germ cell development?

    abstract::Germ cells in many vertebrate and invertebrate species initiate gametogenesis by forming groups of interconnected cells known as germline cysts. Recent studies using Xenopus, mouse and Drosophila are beginning to uncover the cellular and molecular mechanisms that control germline cyst formation and, in conjunction wit...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Pepling ME,de Cuevas M,Spradling AC

    更新日期:1999-07-01 00:00:00

  • Turning up the Green Light.

    abstract::Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

    journal_title:Trends in cell biology

    pub_type: 杂志文章


    authors: Cassereau J,Courdavault V,Nägerl UV

    更新日期:2020-12-29 00:00:00

  • Complex cellular responses to reactive oxygen species.

    abstract::Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2). This has major implications for s...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Temple MD,Perrone GG,Dawes IW

    更新日期:2005-06-01 00:00:00

  • ErbB receptors: new insights on mechanisms and biology.

    abstract::The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Linggi B,Carpenter G

    更新日期:2006-12-01 00:00:00

  • Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis.

    abstract::Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome mis-segregation into a micronucleus or chromatin br...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ly P,Cleveland DW

    更新日期:2017-12-01 00:00:00

  • Hedgehog morphogen: from secretion to reception.

    abstract::A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule requir...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Gallet A

    更新日期:2011-04-01 00:00:00

  • Virtual gating and nuclear transport: the hole picture.

    abstract::The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole mediators of exchange between the nucleus and the cytoplasm. Small molecules pass through the NPCs unchallenged; however, large macromolecules a...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Rout MP,Aitchison JD,Magnasco MO,Chait BT

    更新日期:2003-12-01 00:00:00

  • Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment.

    abstract::Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O2) and nutrient supply. Whereas normal cells modulate anabolic and catabolic pathways in response to changes in nutrient availability, cancer cells exhibit unregulated growth even under nutrient scarci...

    journal_title:Trends in cell biology

    pub_type: 杂志文章,评审


    authors: Ackerman D,Simon MC

    更新日期:2014-08-01 00:00:00