Amphibian muscle regeneration--dedifferentiation or satellite cells?

abstract：:During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different...

journal_title：Trends in cell biology

authors： Sonneveld S,Verhagen BMP,Tanenbaum ME

更新日期：2020-08-01 00:00:00

abstract：:If eukaryotes arose through a merger between archaea and bacteria, what did the first true eukaryotic cell look like? A major step toward an answer came with the discovery of Lokiarchaeum, an archaeon whose genome encodes small GTPases related to those used by eukaryotes to regulate membrane traffic. Although 'Loki' c...

journal_title：Trends in cell biology

authors： Dey G,Thattai M,Baum B

更新日期：2016-07-01 00:00:00

abstract：:The transport of protein through the secretory pathway of eukaryotic cells relies on small vesicular carriers, which mediate the movement of cargo between different compartments. Here, Meir Aridor and Bill Balch summarize what is currently known about the role of the cytosolic coat complexes in directing the formation...

journal_title：Trends in cell biology

authors： Aridor M,Balch WE

更新日期：1996-08-01 00:00:00

abstract：:The directional migration of cells within multicellular organisms is governed by gradients of both chemical attractants and repellents in diverse processes, including leukocyte trafficking and neuronal pathfinding in vivo. These complex extracellular environments direct the orchestrated bidirectional trafficking of le...

journal_title：Trends in cell biology

authors： Huttenlocher A,Poznansky MC

更新日期：2008-06-01 00:00:00

abstract：:The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intra...

journal_title：Trends in cell biology

authors： Andrews NW

更新日期：1995-03-01 00:00:00

abstract：:Cell biologists have used photobleaching to investigate the lateral mobility of fluorophores on the cell surface since the 1970s. Fusions of green fluorescent protein (GFP) to specific proteins extend photobleaching techniques to the investigation of protein dynamics within the cell, leading to renewed interest in pho...

journal_title：Trends in cell biology

authors： White J,Stelzer E

更新日期：1999-02-01 00:00:00

abstract：:Stem cell niches are specialized microenvironments where pluripotent cells are maintained to provide undifferentiated cells for the formation of new tissues and organs. The balance between stem cell maintenance within the niche and differentiation of cells that exit it is regulated by local cell-cell communication, to...

journal_title：Trends in cell biology

authors： Tucker MR,Laux T

更新日期：2007-08-01 00:00:00

abstract：:Vesicular transport of proteins and lipids between distinct subcellular compartments is directly responsible for generating and maintaining the structure of the organelles of the secretory and endocytic pathways in eukaryotic cells. Rapid advances in a variety of experimental systems have resulted in the identificatio...

journal_title：Trends in cell biology

authors： Sztul ES,Melançon P,Howell KE

更新日期：1992-12-01 00:00:00

abstract：:Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous...

journal_title：Trends in cell biology

authors： Dalal K,Duong F

更新日期：2011-09-01 00:00:00

abstract：:'Secrete-and-sense cells' can communicate by secreting a signaling molecule while also producing a receptor that detects the molecule. The cell can potentially 'talk' to itself ('self-communication') or talk to neighboring cells with the same receptor ('neighbor communication'). The predominant forms of secrete-and-se...

journal_title：Trends in cell biology

authors： Doğaner BA,Yan LKQ,Youk H

更新日期：2016-04-01 00:00:00

abstract：:Scientific research relies on a range of technologies, many of which are developing at a fast pace. Technical experts able to advise researchers on experimental design and validate the performance1 of shared instruments are increasingly recognized as critical members of the research community. Here I describe a novel ...

journal_title：Trends in cell biology

authors： Waters JC

更新日期：2020-09-01 00:00:00

abstract：:The vascular system matures during embryonic development to form a stable, well-organized tubular network. In vivo data have established that the extracellular matrix (ECM) is crucial in providing structural support to the vascular system. In vitro studies are defining the involvement of ECM-smooth-muscle cell signali...

journal_title：Trends in cell biology

authors： Brooke BS,Karnik SK,Li DY

更新日期：2003-01-01 00:00:00

abstract：:Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al., Cell, 2019) used the discovery of an inhibitor of xenophagy, SopF,...

journal_title：Trends in cell biology

authors： Pao KC,Rape M

更新日期：2019-10-01 00:00:00

abstract：:A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated prote...

journal_title：Trends in cell biology

authors： Tsegaye MA,Schafer ZT

更新日期：2017-11-01 00:00:00

abstract：:Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant ...

journal_title：Trends in cell biology

authors： Odle RI,Florey O,Ktistakis NT,Cook SJ

更新日期：2021-02-01 00:00:00

abstract：:Fluorescent proteins (FPs) have become indispensable tools in biological research for labeling cells and proteins and sensing their biochemical activity. By introducing 'folding mutations', Campbell et al. engineered a new GFP variant with dramatically enhanced cellular brightness and stability, facilitating advanced ...

journal_title：Trends in cell biology

authors： Cassereau J,Courdavault V,Nägerl UV

更新日期：2020-12-29 00:00:00

abstract：:Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function...

journal_title：Trends in cell biology

authors： Joshi U,Houwman JA,van der Sluijs P

更新日期：2018-10-01 00:00:00

abstract：:The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential f...

journal_title：Trends in cell biology

authors： Spencer WJ,Lewis TR,Pearring JN,Arshavsky VY

更新日期：2020-11-01 00:00:00

abstract：:Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated th...

journal_title：Trends in cell biology

authors： Wei C,Yu P,Cheng L

更新日期：2020-10-01 00:00:00

abstract：:The proliferation of eukaryotic cells is a highly regulated process that depends on the precise duplication of chromosomal DNA in each cell cycle. Regulation of the replication licensing system, which promotes the assembly of complexes of proteins termed Mcm2-7 onto replication origins, is responsible for preventing r...

journal_title：Trends in cell biology

authors： Blow JJ,Hodgson B

更新日期：2002-02-01 00:00:00

abstract：:Recent work has revealed that mitochondria and chloroplasts are subject to direct control by the ubiquitin-proteasome system (UPS). Ubiquitin E3 ligases are present at the outer membrane of both organelles where they mediate ubiquitination and turnover of other organellar proteins. Both organelles exhibit remarkable s...

journal_title：Trends in cell biology

authors： Ling Q,Jarvis P

更新日期：2013-08-01 00:00:00

abstract：:Microtubules have been regarded as essential structures for stable neuronal morphology but new studies are highlighting their role in dynamic neuronal processes. Recent work demonstrates that the microtubule cytoskeleton has an active role during different phases of neuronal polarization - microtubules and their stabi...

journal_title：Trends in cell biology

authors： Hoogenraad CC,Bradke F

更新日期：2009-12-01 00:00:00

abstract：:Research performed over the past decade has transformed apoptosis from a distinctive form of cell death known only by its characteristic morphology and genomic destruction to an increasingly well understood cellular disassembly pathway remarkable for its complex and multifaceted regulation. Here, we summarize current ...

journal_title：Trends in cell biology

authors： Kaufmann SH,Hengartner MO

更新日期：2001-12-01 00:00:00

abstract：:Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O2) and nutrient supply. Whereas normal cells modulate anabolic and catabolic pathways in response to changes in nutrient availability, cancer cells exhibit unregulated growth even under nutrient scarci...

journal_title：Trends in cell biology

authors： Ackerman D,Simon MC

更新日期：2014-08-01 00:00:00

abstract：:Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is widely used during development and by many types of adult stem cells during tissue homeostasis and regeneration. ACD can be regulated by extrinsic cues, such as signaling molecules, as well as by intrinsic factors, such as orga...

journal_title：Trends in cell biology

authors： Xie J,Wooten M,Tran V,Chen X

更新日期：2017-07-01 00:00:00

abstract：:Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is ...

journal_title：Trends in cell biology

authors： Amson R,Pece S,Marine JC,Di Fiore PP,Telerman A

更新日期：2013-01-01 00:00:00

abstract：:Long-distance cell-cell communication is essential for organ development and function. Whereas neurons communicate at long distances by transferring signals at sites of direct contact (i.e., at synapses), it has been presumed that the only way other cell types signal is by dispersing signals through extracellular flui...

journal_title：Trends in cell biology

authors： Kornberg TB,Roy S

更新日期：2014-06-01 00:00:00

abstract：:Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome mis-segregation into a micronucleus or chromatin br...

journal_title：Trends in cell biology

authors： Ly P,Cleveland DW

更新日期：2017-12-01 00:00:00

abstract：:In higher eukaryotes, the vast majority of protein-coding genes contain introns that must be removed from precursor mRNA (pre-mRNA) with great precision by the spliceosome. Spliceosomes are massive RNA-protein macromolecular machines with >100 distinct components that assemble onto nascent transcripts and are released...

journal_title：Trends in cell biology

authors： Rino J,Carmo-Fonseca M

更新日期：2009-08-01 00:00:00

abstract：:Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Galpha subunits of heterotrimeric G proteins. Their ability to dampen signalling via Galphai-, Galphaq- and Galpha12/13-coupled pathways makes them crucial players in mediating the multitude...

journal_title：Trends in cell biology

authors： De Vries L,Gist Farquhar M

更新日期：1999-04-01 00:00:00